Protein Info for Shew_0511 in Shewanella loihica PV-4

Annotation: HlyD family type I secretion membrane fusion protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 441 transmembrane" amino acids 32 to 49 (18 residues), see Phobius details TIGR01843: type I secretion membrane fusion protein, HlyD family" amino acids 26 to 441 (416 residues), 429.8 bits, see alignment E=5.8e-133 PF26002: Beta-barrel_AprE" amino acids 330 to 418 (89 residues), 77.5 bits, see alignment E=7.1e-26

Best Hits

KEGG orthology group: K02022, (no description) (inferred from 100% identity to slo:Shew_0511)

Predicted SEED Role

"HlyD family secretion protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QA85 at UniProt or InterPro

Protein Sequence (441 amino acids)

>Shew_0511 HlyD family type I secretion membrane fusion protein (RefSeq) (Shewanella loihica PV-4)
MNDSQLTQRSWPEHEFTEAVEAPAEKRAIRRITFFIATAVFILLIWSIFTNIEEIAKAKG
QVVPLGHRQVIQSQTGGTLASIAVAEGDLVQKGDLIANFVATDSQALKEELQSKQANLEL
KIERYTAFLEEREPDFNAYQLGFPALVAQHINALARMNQEKQAIIALSESDVAKSEAELA
SVEQEITPLKDQIRSVEQTLKMMNSVKEQQAVSKLRMLESQQKLDAYIRELKVLEGRRSV
LQRNIDNQEKQLAQKQASLFNEVGEKRTDAQAELLGIVARLKSSDSLVQQNRVTSPVDGI
IQSIPNNSAGSVIQPGGTVAVIVPTTPTALLEAKLSPRDIGFVTVGQKARIKIDAFDYSR
YGAIDGLVKKISPSTDADEKGGVFYKVQIAIDKPYFGDQPDKLALIPGMTGEADIVTGDK
TVFQYLWKPVFTNVTEAFGER