Protein Info for Shew_0466 in Shewanella loihica PV-4

Annotation: acriflavin resistance protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1024 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 335 to 354 (20 residues), see Phobius details amino acids 361 to 381 (21 residues), see Phobius details amino acids 387 to 413 (27 residues), see Phobius details amino acids 434 to 452 (19 residues), see Phobius details amino acids 464 to 486 (23 residues), see Phobius details amino acids 523 to 543 (21 residues), see Phobius details amino acids 865 to 884 (20 residues), see Phobius details amino acids 891 to 911 (21 residues), see Phobius details amino acids 917 to 938 (22 residues), see Phobius details amino acids 963 to 981 (19 residues), see Phobius details amino acids 989 to 1016 (28 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1015 (1012 residues), 544.9 bits, see alignment E=1.8e-167

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0466)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QA40 at UniProt or InterPro

Protein Sequence (1024 amino acids)

>Shew_0466 acriflavin resistance protein (RefSeq) (Shewanella loihica PV-4)
MNFAEYSITHKVVSWMFALLLLIGGSLSFMSLGQLEFPEFTIKEALVVTAYPGASPEQVE
EEVTLPLEDALQQLDGVKHITSINSAGLSQIQIEMEDKYDAEKLPQIWDLVRRKVSDTQG
SLPSGAMTPQVIDDFGDVYGILLNLSGDGYSERELENYADFLRRELVLVDGIKRVNIAGI
VDQQVVVEISTQKINALGLNQDYIYGLINSQNVVSNAGSIRVGDNRIRIHPTGEFDSVEA
LSRLVVSAPGSAKLIYLGDIANIYKAMDETPSNLYHSGGDMALSVGIAFSSGVNVVKVGE
AVNQKMMALSDELPVGMMLTTVYDQSKMVDQTINGFLVNLAESIAIVIGVLLIFMGLRSG
LLMGLVLLLTILGTFIMMKVLNIELQIISLGALIIALGMLVDNAIVVTEGIIIGLKRGQS
RLETAKQVITQTQWPLLGATVIAIIAFAPIGLSDNATGEFCISLFLVLLISLFISWITAM
TLTPFFCDLLFKDGEIPDEADSDPYKGWLFQLYRGSLSLAMRFRGLTLLVVLLALVGSVM
GFGQVKNVFFPASNTPIFFVDVWMPEGSDIKATEALLGRIEQDLMAEQEKQDLGLVNITS
VVGQGAQRFVLPYVPEKGYAAYGQLLIEMSNLETLNAYMRRLEQDLVQHYPEAEYRFKYM
ENGPSPAAKIEARFYGEDPEVLRQLAQQASEIFLAEPSATSVRHNWRNQVTLVRPQLALA
QARETGISKQDLDNALLTNFSGKHVGLYRENSHLLPIIARAPADERLNADSISALQVWST
ENNVFVPISQVVSDFTTEWEDPLIMRRDRKRVISVLADPLNGGNETADSVFRKLRPKVEA
ISLPAGYELEWGGEYETSSEAQQSVFSSIPLGYLAMFLITVLLFNSVRQPLVIWFTVPLA
LIGVVSGLLLFDAPFSFMALLGLLSLTGMIIKNGIVLVDQINLELSQGKDAYRAVFDSSV
SRVRPVLMAAITTMLGMIPLLPDAFFGSMAITIIFGLGFASVLTLVVLPVAYTLVFGIKV
PKTA