Protein Info for Shew_0440 in Shewanella loihica PV-4

Annotation: methyltransferase type 12 (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 284 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF01209: Ubie_methyltran" amino acids 54 to 183 (130 residues), 29 bits, see alignment E=2e-10 PF13489: Methyltransf_23" amino acids 56 to 182 (127 residues), 40.1 bits, see alignment E=9.8e-14 PF13847: Methyltransf_31" amino acids 70 to 179 (110 residues), 40.1 bits, see alignment E=8.8e-14 PF13649: Methyltransf_25" amino acids 72 to 171 (100 residues), 52.9 bits, see alignment E=1.5e-17 PF08242: Methyltransf_12" amino acids 73 to 173 (101 residues), 59.9 bits, see alignment E=1.1e-19 PF08241: Methyltransf_11" amino acids 73 to 174 (102 residues), 58.6 bits, see alignment E=2.5e-19

Best Hits

KEGG orthology group: K06219, S-adenosylmethionine-dependent methyltransferase (inferred from 100% identity to slo:Shew_0440)

Predicted SEED Role

"S-adenosylmethionine-dependent methyltransferase Functionally Coupled to the MukBEF Chromosome Partitioning Mechanism" in subsystem MukBEF Chromosome Condensation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QA14 at UniProt or InterPro

Protein Sequence (284 amino acids)

>Shew_0440 methyltransferase type 12 (RefSeq) (Shewanella loihica PV-4)
MRVAPAYGKIALLISVSFSHGRHSVQDKNFDALAGKFAKNIYGTPKGEVRAAVLWRDISQ
AMTQLPEGPLRILDAGGGFGFFSQKLAKLGHSVTLCDISSEMLALGQAQITEYENNSGEK
LDITLLHAPIQSLTREELGQFDLILCHAVAEWLSDAKQTLAGLTQLLKPQGLFSLMFYNK
EAMRFHSLISGNFDYVAADFKVKKKVGLTPSYPLYIDDVRGWVSDWQMELVTASGVRVIH
DYLKTHQPPNSDFSQLLEMELQYSTHPAYIGLGRYVHFITRWQR