Protein Info for Shew_0410 in Shewanella loihica PV-4

Annotation: peptidase U62, modulator of DNA gyrase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 482 PF01523: PmbA_TldD_1st" amino acids 37 to 99 (63 residues), 57.8 bits, see alignment E=1.6e-19 PF19290: PmbA_TldD_2nd" amino acids 125 to 239 (115 residues), 75 bits, see alignment E=1.1e-24 PF19289: PmbA_TldD_3rd" amino acids 247 to 480 (234 residues), 230.7 bits, see alignment E=1.9e-72

Best Hits

Swiss-Prot: 65% identical to TLDD_SHIFL: Metalloprotease TldD homolog (tldD) from Shigella flexneri

KEGG orthology group: K03568, TldD protein (inferred from 100% identity to slo:Shew_0410)

MetaCyc: 65% identical to metalloprotease subunit TldD (Escherichia coli)
3.4.24.-

Predicted SEED Role

"TldD protein, part of TldE/TldD proteolytic complex"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q9Y4 at UniProt or InterPro

Protein Sequence (482 amino acids)

>Shew_0410 peptidase U62, modulator of DNA gyrase (RefSeq) (Shewanella loihica PV-4)
MPFLTQVEQSLLQDGLSLDQLQGYINSIHQHQVDFSDLYFQGSRHESWVLEDGIVKEGSF
HIERGVGVRAISGEKTGFAYADEITPAALSAAVEAARGISAAGNSGRVQAWKQHKVTPLY
QSADPIAAMEEVKKIALLKQADAYVRSLDPRIIQVVISLSGVHEEILVAASDGTLAADIR
PLVRFNCSVVLEQEGKRERGASGGGGRHDYQVFFESGDDGLPSCFAFAREAVRQASVNLT
AIDAPAGEMPVVLGAGWPGVLLHEAVGHGLEGDFNRKGSSAFSGLVGQQVASSLVTVVDD
GTLENRRGSLSIDDEGVPTQKTVLIQDGILKGYMQDKLNGRLMGQASTGNGRRESYAHLP
MPRMTNTYMEAGDSSPEDIIKSVDKGIYAPNFGGGQVDITSGKFVFSASEAYLIEKGEIT
QAIKGATLIGNGPEAMGQLSMVGNDLALDKGVGVCGKDGQSVPVGVGQPSLKLDRLTVGG
TA