Protein Info for Shew_0319 in Shewanella loihica PV-4

Name: cyaA
Annotation: adenylate cyclase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 806 PF12633: Adenyl_cycl_N" amino acids 6 to 203 (198 residues), 198.1 bits, see alignment E=1.6e-62 PF01295: Adenylate_cycl" amino acids 213 to 796 (584 residues), 717.2 bits, see alignment E=1.8e-219

Best Hits

KEGG orthology group: K05851, adenylate cyclase, class 1 [EC: 4.6.1.1] (inferred from 100% identity to slo:Shew_0319)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q9P3 at UniProt or InterPro

Protein Sequence (806 amino acids)

>Shew_0319 adenylate cyclase (RefSeq) (Shewanella loihica PV-4)
MKEQEHFIATAERLNKVRLARALAMLTPLQRHLMQLIPVLFHYHRSDFPGYNGPMTPSGV
FEYFPSDDALEACRTLGLSEPQVIHQQQSALYGVYTMGSTASFGQNPKSDIDVWLVYDPT
LADDEIASLQDKSQLLTAWFGQHDLEVNIYLVHPKQFISSSRDGVVQTASLGCENSGSVQ
HWLLLEEFYRSQICLGGKRVAWWPGAEAIESHLFLGDVSNLPASEYFGASLWQLYKGLDK
PHKALLKVMLLEAYASDYPNSNLVTTQVWQRTLAGDFSAFNDAYFLLYQSIEHYLEYKND
KRRLEIVRRCFYLKCGIRLTVAEHPKDWRYYKLQSLVTRWGWSDNLLRTLDQCASWHCGQ
LQWFNEQLNELMLGCYQTLLQFASANKLSDSLKISELGLLTRKLHTYFSEDDKQIISLNR
LWTRSVAEAHLTVIYSHNTKEYYLYRCTPESKNFMGNRAVFHSHSKAKLLIWASLNGVST
AQTQWYAYGEGKGQDKALTKAAKRLPTIMTERRWRASKLDLCQPWHFRQLLFLINFNRDE
TQLWRGQEIIFDYMNANIFSMGRHHRNMVQSLDVICQNSWGEWHCHHFEGNEAILDALVY
ITPGMQRAPQQVKVDVVSCSSRLSTQIERSISQLVHRANRMCTKAKTSSTMVHPLQVGGI
KYGLFFNSKGMVYQDLSESTAFYQRLSKQRMLELPRPDLGNEPFSKIPEVIQDFAAIGAI
QYFLRPGKEGIDVFVLDEKNELNHYVQPGNNLEELVSQVSHHHAFADSYLDNERFNLPQF
FRLVRVDGRLQAQPFGVNVDEAAIEF