Protein Info for Shew_0225 in Shewanella loihica PV-4

Annotation: phosphoheptose isomerase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13580: SIS_2
  • amino acids 9 to 144 (136 residues), 117.9 bits, E=3.4e-38
• PF01380: SIS
  • amino acids 91 to 152 (62 residues), 29 bits, E=8.3e-11

Best Hits

Swiss-Prot: 100% identical to GMHA_SHELP: Phosphoheptose isomerase (gmhA) from Shewanella loihica (strain ATCC BAA-1088 / PV-4)

KEGG orthology group: K12961, DnaA initiator-associating protein (inferred from 100% identity to slo:Shew_0225)

MetaCyc: 47% identical to D-sedoheptulose 7-phosphate isomerase (Aneurinibacillus thermoaerophilus)
RXN0-4301 [EC: 5.3.1.28]

Predicted SEED Role

"Phosphoheptose isomerase (EC 5.3.1.-)" in subsystem Capsular heptose biosynthesis or LOS core oligosaccharide biosynthesis (EC 5.3.1.-)

MetaCyc Pathways

• ADP-L-glycero-β-D-manno-heptose biosynthesis (5/5 steps found)
• GDP-D-glycero-α-D-manno-heptose biosynthesis (1/4 steps found)

KEGG Metabolic Maps

• Biosynthesis of ansamycins
• Galactose metabolism
• Inositol phosphate metabolism
• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.- or 5.3.1.28

Sequence Analysis Tools

See A3Q9E9 at UniProt or InterPro

Protein Sequence (197 amino acids)

>Shew_0225 phosphoheptose isomerase (RefSeq) (Shewanella loihica PV-4)
MLERIKDSFTHSIQTKIDAAEALPESIEKAAEMMVQCLLGGNKILACGNGGSAGDAQHFS
AELLNRYEIERPPLPAIALTTDTSTITAIGNDYSYDEIFSKQILALGQPGDILLAISTSG
NSGNVIKAMEAALSRDMTIVALTGKDGGAMAGLMGTNDVEVRVPSNVTARIQEVHLLVIH
CLCDNIDRTLFPQDDQA