Protein Info for Shew_0105 in Shewanella loihica PV-4

Annotation: peptidase M14, carboxypeptidase A (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 845 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00246: Peptidase_M14" amino acids 60 to 222 (163 residues), 64.9 bits, see alignment E=4.9e-22

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0105)

Predicted SEED Role

"Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q929 at UniProt or InterPro

Protein Sequence (845 amino acids)

>Shew_0105 peptidase M14, carboxypeptidase A (RefSeq) (Shewanella loihica PV-4)
MLRLCLLLLSIVPLLLSFATNAQSVISVASATQSDSSLASPSEFLGYPLGQWHLRHDQIN
YYLKQLAQNSPRVSLESTGQSHETRQQLTAVITSAANQARLAEIVQGRQQVKAGKAPESP
LIIWLAYSIHGDEASGAHAALEVSYRLSQNQEPWVQELLDKAVVLITPSQNPDGLDRFST
WTNNYTGKVKVSDENHNEHRQNWPAGRRNHYFADLNRDWLFLRHPESQGRIALFHKWQPH
YLGDFHEMGHNQTFFFQPGVPTRTHPLTPKENQVITSKLASFHAKALDESKQRYFTKQMF
DDFYYGKGSTYPDINGAVGILFEQASVRGQQQDSENGLLRFSQAINNQIATSFSSLKGAL
ALADELKQYQSRFYQRKDKHPPSGREAGFLLGAPGDPGRRDDLAQLLSRHGIAFFYLKDK
MQQGRHQYSQDDSLFVPINQPQKTLLLAMFDLRTEFEDATFYDVSSWNLAFSYNLQMARN
VNLNVDDLLTEPHARVPDTLSSNNVAVLIDWRQQNAAPMLQTLLSEGVRVKFAAKPFSLK
VDGQSLNMEAGTLQIPVAQAAMTPRELIDRLTSLAEQYRVQLQGVDSGLASSGIDLGSPD
FHDIAPIKALVVTGYGTSSAEVGELWYFMDNLIGAPLTQVDISRLPSIELAAYTHLFLMD
GSYANLDEKYARKLGQFAIEGGVIVAQKGALQWLSKGNLLKSDIREKRYFSQLFATDGLS
FGDKAKLDARQAIGGAVLALDLDTSHPITFGLGTNRLPVLKNKVFGLSKSQAPFITAASY
ADEPLLDGFLAEEYQRSLSQTPAIVVERHGKGALVALADNLLFRNIWLGSQKVYANSLYF
IPALH