Protein Info for Shew_0053 in Shewanella loihica PV-4

Annotation: formate dehydrogenase, subunit FdhD (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02634: FdhD-NarQ
  • amino acids 37 to 269 (233 residues), 257.2 bits, E=8.9e-81

Best Hits

KEGG orthology group: K02379, FdhD protein (inferred from 100% identity to slo:Shew_0053)

Predicted SEED Role

"Formate dehydrogenase chain D (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (5/15 steps found)
• purine nucleobases degradation II (anaerobic) (11/24 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

See A3Q8X8 at UniProt or InterPro

Protein Sequence (281 amino acids)

>Shew_0053 formate dehydrogenase, subunit FdhD (RefSeq) (Shewanella loihica PV-4)
MTSFKHPTLVKTQADAPLTMAVKAINEQGEVVDKYIACERPLTLYLNWRPIVTLMTLGAR
PEALALGYLKNQGFISDVHQLESVIVDWEVNSAAVITKESTAHLEEKLAEKTVTTGCGQG
TVYGGFMDGVEDIRLPTPQLKQSMLYSLLNNISAYNETYKNAGAVHGCGLCEGDQIIGFV
EDVGRHNAVDTLAGEMWLKQQGGGNKLFYTTGRLTSEMVIKVAKMGIPVLLSRSGATQMG
LELAQKLGITMIARAKGRHFLIYHGAENIEFDATPPKRNLG