Protein Info for Shew_0044 in Shewanella loihica PV-4

Annotation: acriflavin resistance protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1036 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 333 to 356 (24 residues), see Phobius details amino acids 362 to 380 (19 residues), see Phobius details amino acids 388 to 409 (22 residues), see Phobius details amino acids 436 to 455 (20 residues), see Phobius details amino acids 467 to 493 (27 residues), see Phobius details amino acids 525 to 544 (20 residues), see Phobius details amino acids 853 to 872 (20 residues), see Phobius details amino acids 879 to 899 (21 residues), see Phobius details amino acids 909 to 930 (22 residues), see Phobius details amino acids 958 to 978 (21 residues), see Phobius details amino acids 985 to 1005 (21 residues), see Phobius details PF00873: ACR_tran" amino acids 5 to 1011 (1007 residues), 599.7 bits, see alignment E=9.6e-184 PF03176: MMPL" amino acids 342 to 517 (176 residues), 24.1 bits, see alignment E=1.7e-09 amino acids 844 to 1016 (173 residues), 40.3 bits, see alignment E=2e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0044)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q8W9 at UniProt or InterPro

Protein Sequence (1036 amino acids)

>Shew_0044 acriflavin resistance protein (RefSeq) (Shewanella loihica PV-4)
MNLTKLSTNNPAGTLVALLLIAIFGVLAIGKLPIQLLPDIQRPQISVFNNWRSAAPQEME
SNIIEPQENVLRQVPGVVEMTSNISQGFGGITLTFEVGSDMQAGMINVINALNQTPPRPL
DANEPFINVGGGNGAPNLASLLIRMAPDNPATDFAQYQKLIDDVVEPRLRLISGVGSVRL
QSRLPKELHIEFDPYRAAALGITLDQLRSTLSRAADISGGTANVGRRQYTVRFIGQYTPE
NLGNLIVTYNEGRPIYLNELADVEVSSADVQGFTKRNGYPAYYMTVEGTFDANTVKVLDG
VNEAIAELNQGPLKEAGLVLDLSFDASVHIKRAIWLVKGNLAIGVVLALVILYAFLRSFR
ATLMIASTIPVALLIAFFFLEMMGRTLNVISLAGLAFAVGLVLDAAIIVQENIVRILQQG
TPIREAIAKGTDQVKGALLASTATTVAIFLPILFMPGVEGQLFSDLALTLSVAVVSSFIS
AITLIPVFSLLWLKLSPQDDGQQSGRLWRWISATVQRLTGDTKRAVFWCVTLILGAAMLT
AVLMPRPDFLPQARSDGIFAFFALPPGANVKTLEKEVGDVIIERLKPYYDKEKQPYIKGY
NFSMYSAFNVLFIYPEDPSQADAMIELLNKEILVGLPDTQAFTNRGSLLQFGFNGGRAIN
IDLQGADMEALMETAGKGMGLIQEALPGAVVRPIPGLSMAQPELQLIPNERRLAQAGVDR
IQIANAIRAYTSGLFVGEYFDGNERMDVLLKGPKWQVPEQLSATPVYTQAAGIQTIGELA
TLKRTVGPTQLQRVNGKRSVSLLIFPPADMSLDEALEKLNQSAVPTLRASLPENSSLGYR
GSADKLDSTIKDMGANFALAVVILFLLMAAMFKSAKDSLLVLLSMPLAICGGVVSLRLLN
LFSFQSLDLLTMIGFIILLGLVVNNAILLVDQTRQSYRETPDIDLAIAQAVATRARPVYM
STLTSIFGMLPLMLVPGVGSEIYRGLAAVIVGGMTFSALFTLILMPSLLRLTHRLSPVTN
RLADEPALSSTTGVKS