Protein Info for Shew_0041 in Shewanella loihica PV-4

Annotation: diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1094 transmembrane" amino acids 37 to 56 (20 residues), see Phobius details amino acids 451 to 475 (25 residues), see Phobius details PF08376: NIT" amino acids 82 to 287 (206 residues), 93.2 bits, see alignment E=1.5e-29 PF00672: HAMP" amino acids 474 to 522 (49 residues), 30.3 bits, see alignment (E = 1.9e-10) TIGR00229: PAS domain S-box protein" amino acids 536 to 653 (118 residues), 65.4 bits, see alignment E=5.5e-22 PF13188: PAS_8" amino acids 537 to 576 (40 residues), 24.5 bits, see alignment (E = 9.1e-09) PF00989: PAS" amino acids 541 to 644 (104 residues), 45.5 bits, see alignment E=3.1e-15 PF13426: PAS_9" amino acids 544 to 645 (102 residues), 62.8 bits, see alignment E=1.4e-20 PF08447: PAS_3" amino acids 557 to 639 (83 residues), 33.6 bits, see alignment 1.8e-11 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 658 to 815 (158 residues), 135.1 bits, see alignment E=2e-43 PF00990: GGDEF" amino acids 659 to 814 (156 residues), 166.1 bits, see alignment E=2.7e-52 PF00563: EAL" amino acids 835 to 1072 (238 residues), 240.3 bits, see alignment E=8.4e-75

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0041)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q8W6 at UniProt or InterPro

Protein Sequence (1094 amino acids)

>Shew_0041 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) (RefSeq) (Shewanella loihica PV-4)
MLLLSDPKFLASAFVIIEQGALKMSSMLNRYSLSQKLILLATIPMLLLLIFGSLRMLDLI
ERQQTAQRNALGVMITEQTQKLIFALQNERGLSAGFVASQGNRFERRLQTQRRQTDKALQ
DLLDAPNIANLHLSLSDIDRPSVNLQQSVDTIHALGARLKQVRQGIDSRTEGSGFNFYSE
FTQHLLVLISQIQSQVQNTLLAKAYNDLIHMLKLQELAGKDRDLLNRLLAADSLDHQAYL
AQYSMQDDLLDAFHEMLSTTSPADLALIKETLDNEATQELLLMKGRVKAQVNLILLANRL
RERLGYGGLIDHYQDYLLSGEETNIILFEEDCLAIQGLLQQAQKLPHVTSPQREALAQID
NTVEQYRQAVDAQRQHRLSGHAGPLPQEGRAIIADQAMLAALSQLQHQHPAVASEAWWAL
ATEALGQMNQASLTLSNNIANLVQRQGREALSFLVLGIMAAMCNFLFLIVLGRLIVNNLV
TRIGTIASLMQRMAQNTQLQLSVPVDGRDEVAKMAMALNAMLSERQEANRELSLASAVFE
YCAEGIVVTDKDNLIEAVNPAFTQITGYTLEEVKGRSPAVLNSHQQPHHFYEQMWQSLKQ
YGKWQGEIWNKRKNGQIFPEYLAITVVKDDKGRVVQHIGLFLDISNRKKYEQDIWYKSNY
DALTNLPNRQLYTSRLSQMLQLAEQRCCSVAVLFIDLDRFKYINDIYGHAVGDELLQVAA
ARLEALLEQHDFVARLSGDEFVVVMGHTKHQGEIEQRAQNILQHLSSPFGINRNELLISA
SVGISCYPSNGTSVEVLTRNAETAMYQAKQDGRNCFGYFSPDMNNNMLARITLEQSLRSA
VLQHEFCLHYQPIVDTSSGEGVALEALLRWRHPQRGLVPPDEFIPIAEETGLIEPIGEWV
IQQALRDLRQCHSQGIMINMAINVSGRQLAHGDPSHFACMLNGLLQKYDVAPQYVHIEIT
ESILMADTELSLKALTAIRHLGVEIYLDDFGTGYSSLSYLKQFPISVIKIDKSFVDNMLE
DRADANLIKAIITMGQSLDMRLVAEGVESEPQRSFLQGLGCDFVQGYLVAKPMPLKELEP
LLRRIVREKPTSLL