Protein Info for Dshi_4195 in Dinoroseobacter shibae DFL-12

Annotation: protein of unknown function DUF112 transmembrane (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 503 transmembrane" amino acids 20 to 47 (28 residues), see Phobius details amino acids 58 to 81 (24 residues), see Phobius details amino acids 110 to 135 (26 residues), see Phobius details amino acids 142 to 160 (19 residues), see Phobius details amino acids 166 to 184 (19 residues), see Phobius details amino acids 196 to 217 (22 residues), see Phobius details amino acids 259 to 280 (22 residues), see Phobius details amino acids 321 to 344 (24 residues), see Phobius details amino acids 356 to 379 (24 residues), see Phobius details amino acids 390 to 409 (20 residues), see Phobius details amino acids 415 to 445 (31 residues), see Phobius details amino acids 465 to 489 (25 residues), see Phobius details PF01970: TctA" amino acids 17 to 440 (424 residues), 463.7 bits, see alignment E=2.4e-143

Best Hits

KEGG orthology group: K07793, putative tricarboxylic transport membrane protein (inferred from 100% identity to dsh:Dshi_4195)

Predicted SEED Role

"Tricarboxylate transport membrane protein TctA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LUI8 at UniProt or InterPro

Protein Sequence (503 amino acids)

>Dshi_4195 protein of unknown function DUF112 transmembrane (RefSeq) (Dinoroseobacter shibae DFL-12)
MEAFMLGAAEVLSLTTLAMMLAGAIAGIIAAAIPGFTVTMAIVLTLPLTFTMDPLQGISV
MLSVYVGGYTGGLISAALLGIPGTPSSVATTFDAFPMARGGEPGRALSLGVWASFFGTVI
STAVLIVAAPPLAVFAVRLGPWEYFSLIVFALTIVASLVGNSLQRGLIAALIGLAISTIG
ADPIMGRPRFDMGWELLRAGLPFLVVLIGIFAISQLASEVEDAKAIKRGEKLVDGDIDFK
TWSVMREVLSRPVNLVRSSMVGVAIGALPGAGGSIANLVAYDQAKRASKTPEAFGTGTPD
GIVASESGNSATAGGGLIPLISLGIPGSAVDAILMASLMVHGISVGPRLIMDNADLVYGM
FIAMAVSSLMMLVVCVVSMRAFLRVAEVPKWVVVPVVLVCCVVGSFALNNRVTDLYLLAA
IGLVGYALKALDYPLAPLVLGVILGPIAETNLRRALMTDADWTLFLTRPVSLIFLVAAVL
SVAWAIRGILKARNQADPGKDPA