Protein Info for Dshi_4113 in Dinoroseobacter shibae DFL-12

Annotation: death-on-curing family protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 130 PF02661: Fic" amino acids 6 to 86 (81 residues), 59.9 bits, see alignment E=1.8e-20 TIGR01550: death-on-curing family protein" amino acids 13 to 112 (100 residues), 52.7 bits, see alignment E=2.2e-18

Best Hits

KEGG orthology group: K07341, death on curing protein (inferred from 100% identity to dsh:Dshi_4113)

Predicted SEED Role

"Death on curing protein, Doc toxin"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LUB3 at UniProt or InterPro

Protein Sequence (130 amino acids)

>Dshi_4113 death-on-curing family protein (RefSeq) (Dinoroseobacter shibae DFL-12)
MTEPFWVSQAGVLRIHDLGLEIGGGAAGLRDAGLLASALARPVNLWAYGETDLFVLAAAY
AEGIAGNHPFVDGNKRTGFMTADVFLARHGWLLSPVTDETHADMMVALARGQIDRGQAAA
HFRDHAAPVP