Protein Info for Dshi_4104 in Dinoroseobacter shibae DFL-12

Annotation: Cobyrinic acid ac-diamide synthase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 397 transmembrane" amino acids 252 to 270 (19 residues), see Phobius details TIGR03453: plasmid partitioning protein RepA" amino acids 12 to 392 (381 residues), 594.6 bits, see alignment E=3.6e-183 PF10609: ParA" amino acids 113 to 288 (176 residues), 31 bits, see alignment E=7.3e-11 PF06564: CBP_BcsQ" amino acids 113 to 274 (162 residues), 32.4 bits, see alignment E=2.9e-11 PF13614: AAA_31" amino acids 113 to 286 (174 residues), 132.8 bits, see alignment E=5.5e-42 PF09140: MipZ" amino acids 114 to 151 (38 residues), 30.7 bits, see alignment 8.1e-11 PF01656: CbiA" amino acids 115 to 354 (240 residues), 86.8 bits, see alignment E=4.8e-28 PF02374: ArsA_ATPase" amino acids 119 to 157 (39 residues), 27.3 bits, see alignment 8.3e-10

Best Hits

Swiss-Prot: 54% identical to REPA_AGRRH: Putative replication protein A (repA) from Agrobacterium rhizogenes

KEGG orthology group: None (inferred from 100% identity to dsh:Dshi_4104)

Predicted SEED Role

"Plasmid replication protein RepA" in subsystem Plasmid replication

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LUA4 at UniProt or InterPro

Protein Sequence (397 amino acids)

>Dshi_4104 Cobyrinic acid ac-diamide synthase (RefSeq) (Dinoroseobacter shibae DFL-12)
MSELEQDLDIAIGHYAELLASNLHAQRAAHFPPDAKKVMRTLTSGEAAELLGVDHTYLRK
LHREGKIVDVETTAGSHRRYTLDDIWEIRQTLEGTAKKSGTYVPGRRDGDELQVISVVNF
KGGSGKTTTSAHLAQRLALKGYRVLAIDLDPQASLSALHGIQPELDLMEGGTLYDAVRYD
DPVPIAEVIRKTYIRGLDLIPGNLELMEFEHETPAAIQRGGAKAFFARVHDALDSVEANY
DVVVIDCPPQLGFLTMSALSASSGVLVTVHPQMLDLMSMSQFLRMTADLLGVIRDAGANL
RFDWLRFLPTRYKVGDAPQTEVIAFIRGLFGRSILTNHMVESTAISDAGLTKQTLYEADK
KDFTRQTFDRAIESMNAVNDEIAEIIQNTWGRNGKKA