Protein Info for Dshi_3905 in Dinoroseobacter shibae DFL-12

Annotation: MscS Mechanosensitive ion channel (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 373 transmembrane" amino acids 21 to 46 (26 residues), see Phobius details amino acids 68 to 88 (21 residues), see Phobius details amino acids 96 to 117 (22 residues), see Phobius details amino acids 146 to 165 (20 residues), see Phobius details amino acids 171 to 191 (21 residues), see Phobius details PF00924: MS_channel_2nd" amino acids 193 to 259 (67 residues), 43.9 bits, see alignment E=1e-15

Best Hits

KEGG orthology group: None (inferred from 100% identity to dsh:Dshi_3905)

Predicted SEED Role

"membrane protein, putative"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LTR6 at UniProt or InterPro

Protein Sequence (373 amino acids)

>Dshi_3905 MscS Mechanosensitive ion channel (RefSeq) (Dinoroseobacter shibae DFL-12)
MEEITSQIARWGDLIEGLPAFLAPAALLLAAVVAALQLHALAFALLSRFTKTNCGVVGSL
AERARRPLRLAFILAALAITIPQIGLPYRWESRLGHLFLVLLIVLVGWTVIILTSHFSDR
AIRRHRLDTDDNLQARKFVTQVRVLKRTANIVFGILTAGAVLLTFESVQRYGVSLFASAG
AAGLILGFAARPVLANLIAGIQIAITQPIRLDDVVIVEGEWGWIEEIYATYVVVRIWDWR
RMVVPLSYFIEKPFQNWTRENASIIGAVYWYMDYTVPIAEMRAKLEKTVENSPHWDGQVV
NLQVTDTDKDTLHIRGLMSARTSPQAWDLRCEVREKLIAWLQAEYPEALPRLRGELEMRP
ERASGSLEQADAA