Protein Info for Dshi_3891 in Dinoroseobacter shibae DFL-12

Annotation: Cytochrome c oxidase subunit I type (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 853 transmembrane" amino acids 62 to 84 (23 residues), see Phobius details amino acids 105 to 129 (25 residues), see Phobius details amino acids 141 to 160 (20 residues), see Phobius details amino acids 187 to 213 (27 residues), see Phobius details amino acids 225 to 251 (27 residues), see Phobius details amino acids 277 to 300 (24 residues), see Phobius details amino acids 309 to 330 (22 residues), see Phobius details amino acids 342 to 368 (27 residues), see Phobius details amino acids 380 to 404 (25 residues), see Phobius details amino acids 417 to 438 (22 residues), see Phobius details amino acids 450 to 472 (23 residues), see Phobius details amino acids 494 to 516 (23 residues), see Phobius details amino acids 607 to 623 (17 residues), see Phobius details amino acids 629 to 649 (21 residues), see Phobius details amino acids 680 to 704 (25 residues), see Phobius details amino acids 719 to 740 (22 residues), see Phobius details amino acids 752 to 776 (25 residues), see Phobius details amino acids 782 to 807 (26 residues), see Phobius details amino acids 827 to 850 (24 residues), see Phobius details TIGR02891: cytochrome c oxidase, subunit I" amino acids 50 to 553 (504 residues), 696.7 bits, see alignment E=8.5e-214 PF00115: COX1" amino acids 58 to 503 (446 residues), 493.2 bits, see alignment E=3.5e-152

Best Hits

KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 100% identity to dsh:Dshi_3891)

Predicted SEED Role

"Cytochrome c oxidase polypeptide I (EC 1.9.3.1) / Cytochrome c oxidase polypeptide III (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LTQ2 at UniProt or InterPro

Protein Sequence (853 amino acids)

>Dshi_3891 Cytochrome c oxidase subunit I type (RefSeq) (Dinoroseobacter shibae DFL-12)
MTDTFPQPRGAEPPSPQPAARKPAYDVAPKGEMGKDFEGIWEQPSGIRVLSAVSHRAVGK
RFLITGFIFFLIAGVFALLVRLQLMVPENTFLSSETYNQLFTMHGTIMMFLFAIPMLEGF
AVYLIPLMIGARDLVFPRLGAFGYYCYLFGGIIVLSSFLFDAAPDGGWFMYVPLSTSAYT
EGLSADFWLIGITLAEIASVTAAVEIIAAILCSRAPGMSLTKMPILMWYLLATAFMIAIA
FPPLIIGSILLEAERLLGLPFFDHTLGGDPLLWQHLFWLFGHPEVYIIFLPAAGMVATML
PTFVGKPLFGYGFAVAAVVTMSFLSFGLWAHHMFATGLPILSLSLFSAASTMVAVPTGVQ
IFCFIATLSQGKPRLTVPMHFILGFLFIFVLGGMTGVMVAAVPFNLQAHDSYFVVAHLHY
VLIGGMVFPMFGALYYWVPHFTGRMMSERLGKWVFWLMFSGFNLAFFMMHLTGMRGMPRR
VATYPGGIGWDRLNMLSTIGAFILAAGIALFIWDFFRHRRVGPRAGRNPWGASTLEWLYE
PVTPGYNFRAIPRITSREPLWDQPELAETPGAEVRGALRDYPDHRRETLGCHIVTGEPLQ
ILRLPHPTWFPLIAALGLALLFGATLASVYWLCAIGAGIALIGFAGWAWEPSDSGVDRDI
GIEGLRLPVNAIDKQSHLHVGLVGTIMILFALFFSLLFAGLYLWNTQPIFAEATQRPARI
FALLALGLSVVVFALSWMVGRAHARASLWMTGSLNILLAACLIGLTMCFGLALLPIDPWS
TAFAAVGWAIGAYLTALISVALLWTVFNALRKAVGATKPGQGLPDMLLGSFGKATATMAL
ITAIAFLFAGTPQ