Protein Info for Dshi_3805 in Dinoroseobacter shibae DFL-12

Annotation: NADH dehydrogenase (quinone) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 969 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 33 to 55 (23 residues), see Phobius details amino acids 76 to 101 (26 residues), see Phobius details amino acids 113 to 130 (18 residues), see Phobius details amino acids 136 to 155 (20 residues), see Phobius details amino acids 167 to 190 (24 residues), see Phobius details amino acids 210 to 235 (26 residues), see Phobius details amino acids 247 to 268 (22 residues), see Phobius details amino acids 275 to 296 (22 residues), see Phobius details amino acids 303 to 321 (19 residues), see Phobius details amino acids 327 to 351 (25 residues), see Phobius details amino acids 372 to 393 (22 residues), see Phobius details amino acids 413 to 434 (22 residues), see Phobius details amino acids 455 to 478 (24 residues), see Phobius details amino acids 506 to 524 (19 residues), see Phobius details amino acids 568 to 588 (21 residues), see Phobius details amino acids 601 to 622 (22 residues), see Phobius details amino acids 629 to 647 (19 residues), see Phobius details amino acids 653 to 671 (19 residues), see Phobius details amino acids 692 to 710 (19 residues), see Phobius details amino acids 750 to 768 (19 residues), see Phobius details amino acids 792 to 814 (23 residues), see Phobius details amino acids 824 to 845 (22 residues), see Phobius details amino acids 857 to 876 (20 residues), see Phobius details amino acids 898 to 920 (23 residues), see Phobius details PF00662: Proton_antipo_N" amino acids 70 to 115 (46 residues), 36.2 bits, see alignment 1.2e-12 PF00361: Proton_antipo_M" amino acids 131 to 409 (279 residues), 223.1 bits, see alignment E=1.2e-69 PF13244: MbhD" amino acids 612 to 676 (65 residues), 67.7 bits, see alignment 2e-22 PF20501: MbhE" amino acids 686 to 765 (80 residues), 89.3 bits, see alignment E=3.5e-29 PF04039: MnhB" amino acids 794 to 916 (123 residues), 130.7 bits, see alignment E=9.7e-42

Best Hits

KEGG orthology group: K05559, multicomponent K+:H+ antiporter subunit A (inferred from 100% identity to dsh:Dshi_3805)

Predicted SEED Role

"Na(+) H(+) antiporter subunit A / Na(+) H(+) antiporter subunit B" in subsystem Sodium Hydrogen Antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LTG8 at UniProt or InterPro

Protein Sequence (969 amino acids)

>Dshi_3805 NADH dehydrogenase (quinone) (RefSeq) (Dinoroseobacter shibae DFL-12)
MSHEGSFLFIIALLPFLGALVPGLMIRAGRTACASFTAVPTALAFIMLLILSPAVLRGEV
ITAEIGWLPQLGLSASFFLDGLGLLFALMITGVGLLIILYARFYLSGDDPMGQFYTYLLL
FQGAMLGIVLSDNILLLLIFWELTSLSSFLLIGYWKHLPEGRQGARMALAVTGAGGLAMI
GGMLILGNIVGSYNLTDILQAGEQIRASEWYLPALILILLGAFTKSAQFPFHFWLPHAMA
APTPVSAYLHSATMVKAGVFLMARMWPVLAGTDAWFYIVATTGLVTMVMGAGIALFKDDL
KALLAFSTVSHLGLLTMLLGFGTQAAAVAAVFHIINHLTFKAALFMTAGIVDHETHTRDI
KRLGGLRHLMPITFAIGTVAALSMAGIPLFNGFLSKEMMLEEASHTGWLGNPWVVPVVAT
FGALLSVAYSFRFIGHVFLGPVRDDYPAKPHDPPFGMWASPALLVVLVLVIGMAPFVAEG
IVTAASSAVTGADLHPHLKIWHGFTPALWMSVVATLGGLMLLALHGKLDPIWQAARRPEA
KAIFDGLVAGLVALTRGITERTHTGKISAYLALFTVSSVALGWIAYAGSGLSLPTRELLP
VPPVIAVGWLMLVVATASVVVMHHQRFQALILIGIIGLSISAGFVYLSAPDLALTQVSVE
TVTIMLLLLALHFLPKTTPKESSLGRKIRDGAIAVTAGGGVGALAFAFLLRDVETISGFH
LENSYEGGGGTNVVNVILVDFRGYDTYGEIIVLGIAGLVIYALMQALLDGPAARRLRSGD
FSNDRSRDRHPMMMVVVTRVLMPIAVVVGLYIFLRGHNEPGGGFVAGLVIAIALLMQYMA
SGFAWTQERKRIEYHTMIGLGVIIAGLTGAGAWLLGRPFLTSAYTYINLPPIEEFELATA
MLFDLGVFLTVLGAVMLMLYSLSRIARFAGETVNTGPMDYDPAVKGSVGTPPRPAEPPTP
VRPGPEGAR