Protein Info for Dshi_2998 in Dinoroseobacter shibae DFL-12

Annotation: MscS Mechanosensitive ion channel (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 826 signal peptide" amino acids 1 to 41 (41 residues), see Phobius details transmembrane" amino acids 178 to 196 (19 residues), see Phobius details amino acids 216 to 244 (29 residues), see Phobius details amino acids 255 to 277 (23 residues), see Phobius details amino acids 301 to 321 (21 residues), see Phobius details amino acids 327 to 351 (25 residues), see Phobius details amino acids 372 to 396 (25 residues), see Phobius details amino acids 409 to 427 (19 residues), see Phobius details amino acids 455 to 476 (22 residues), see Phobius details amino acids 496 to 517 (22 residues), see Phobius details amino acids 538 to 561 (24 residues), see Phobius details amino acids 567 to 586 (20 residues), see Phobius details PF21088: MS_channel_1st" amino acids 547 to 587 (41 residues), 30.2 bits, see alignment 5.2e-11 PF00924: MS_channel_2nd" amino acids 589 to 652 (64 residues), 56.8 bits, see alignment 3e-19 PF21082: MS_channel_3rd" amino acids 659 to 746 (88 residues), 24.5 bits, see alignment E=4.6e-09

Best Hits

KEGG orthology group: None (inferred from 100% identity to dsh:Dshi_2998)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LKE8 at UniProt or InterPro

Protein Sequence (826 amino acids)

>Dshi_2998 MscS Mechanosensitive ion channel (RefSeq) (Dinoroseobacter shibae DFL-12)
MHTPSAPMALCAARFVFLRGFLVAVATLLALVLGSWTASAQSTFPIPGMTGNSSTEAPAE
DAPAEATTPADPTQALIELLQDEAARAALIAQLEQAAAGTAAAPEGSATAPAAAAPEATT
TTTSTVGNFSTRLIQDLRTTMADNLRGFMARVERIPTTLGLAIRGLNSDLLLTIVRDLVE
AVLVTYGALILLRLAMRPLLRMIGRKAVSTNWLYRFILRIIGTGLLALAIPIALVIGVAV
VSVSVVAENGASLNTAQAAFFAAFALVEMLKLPSRFVLTPRTDQLRFIDVSDKAARQIQR
LIAFAIGLAAYGQLVAVPVVTEQTSVFIGRAVATLLGAIVIVYLVGVVLAYRKKVGAWLT
RYSKEDVTLDEVLSYFALRWHWPVLAYLVYVLVVVLTRPGNVLGPLAADTVRVVLILGIG
GTVTMLARRATQRRVRLPEMVDSRLPLLASRLNRLLPAGLVVVRIAVVILVVLSILDVVE
LFDFSGYLGSDAGGAMVGAIFGVALGLVFVAVVYLAVSSWVDYQLNPFVGKPPTPRTVTL
LTLLRNAVTIALVIFGGMFALSQLGLNIGPLLASAGVLGLAISFGAQKLVEDIITGIFIQ
FENAMNVGDVVDVGGVVGTVEKLTVRSVTLRDLQGVVHMIPFSSASMISNYMREFSYYVC
DMGVAYREDIEMAKQAMFDAFEELRADPDQGGFLIDDLEWFGLNSFGDSAIVLRARIKTQ
PGKQWGVGRAYNLLLKKIFDDRGIEIPFPHQTIYFGEDRKGKAPPIHVMMQTGDAAASQA
HPVTEAIPDARGPEQLEMDETRRRQVPPDRGDETIPGQEDDDGAGR