Protein Info for Dshi_2383 in Dinoroseobacter shibae DFL-12
Annotation: Cytochrome c oxidase subunit I type (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 83% identical to COX1B_PARDE: Cytochrome c oxidase subunit 1-beta (ctaDII) from Paracoccus denitrificans
KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 100% identity to dsh:Dshi_2383)Predicted SEED Role
"Cytochrome c oxidase polypeptide I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)
MetaCyc Pathways
- aerobic respiration I (cytochrome c) (3/4 steps found)
- arsenite to oxygen electron transfer (1/2 steps found)
- aerobic respiration II (cytochrome c) (yeast) (2/4 steps found)
- arsenite to oxygen electron transfer (via azurin) (1/3 steps found)
- Fe(II) oxidation (2/6 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.9.3.1
Use Curated BLAST to search for 1.9.3.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A8LRT8 at UniProt or InterPro
Protein Sequence (558 amino acids)
>Dshi_2383 Cytochrome c oxidase subunit I type (RefSeq) (Dinoroseobacter shibae DFL-12) MADAAIHGHGHEDTRGFFTRWFMSTNHKDIGILYILVAGLAGFISVAFTVYMRMELMNPG VQYMCTEGARFIAAGANDVCTPNGHLWNVLITGHGILMMFFVVIPALFGGFGNYFMPLHI GAPDMAFPRLNNLSFWLYVAGTSLAIASVLAPGGNGQTGSGVGWVLYPPLSTTEAGFSMD LAIFAVHVSGASSILGAINIITTFLNMRAPGMTLFKVPLFAWSIFVTAWLILLALPVLAG AITMLLTDRNFGTTFFDPAGGGDPVLYQHILWFFGHPEVYIVILPAFGIISHVIATFSRK PVFGYMPMVWAMIAIGGLGFVVWAHHMYTVGMSLTQQSYFMLATMVIAVPTGVKIFSWIA TMWKGSLTFETPMLFAIGFLFLFTVGGVTGIVLSQAGVDRAYHDTYYVVAHFHYVMSLGA VFGIFAGIYFWIGKMSGRQYPEWAGKVHFWTFFIGTNITFFPQHFLGRQGMPRRYIDYPE AFGLWNWVSSWGAFLSFASFLFFIGVVFYTITRGKRVEEENYWNEHADTLEWTLPNPPPE HTFEQLPTRDMWDKQPSH