Protein Info for Dshi_2273 in Dinoroseobacter shibae DFL-12

Annotation: Homoserine dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03447: NAD_binding_3
  • amino acids 11 to 131 (121 residues), 56.6 bits, E=6.3e-19
• PF00742: Homoserine_dh
  • amino acids 139 to 317 (179 residues), 204.2 bits, E=2.1e-64
• PF01842: ACT
  • amino acids 349 to 410 (62 residues), 44.1 bits, E=2e-15

Best Hits

KEGG orthology group: K00003, homoserine dehydrogenase [EC: 1.1.1.3] (inferred from 100% identity to dsh:Dshi_2273)

Predicted SEED Role

"Homoserine dehydrogenase (EC 1.1.1.3)" in subsystem Methionine Biosynthesis or Threonine and Homoserine Biosynthesis (EC 1.1.1.3)

MetaCyc Pathways

• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• aspartate superpathway (21/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (8/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (8/9 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (7/8 steps found)
• L-homoserine biosynthesis (3/3 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Glycine, serine and threonine metabolism
• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.3

Sequence Analysis Tools

See A8LR86 at UniProt or InterPro

Protein Sequence (428 amino acids)

>Dshi_2273 Homoserine dehydrogenase (RefSeq) (Dinoroseobacter shibae DFL-12)
MSSPLRLGIAGLGTVGAGVVKIISRKQELLAARAGRPIEVTAVSARSRDKDRGVDMSTYG
WENDPVALARRDDVDVFVELMGGEDGPARNATEAALAAGKDVVTANKAMLAHHGQALAMA
AEDAGRVIRFEAAVAGGIPVIKALTEGLAGNEITRVMGVMNGTCNYILTRMEAEGLGYNI
LFEEAGKLGYLEADPTLDVGGIDAAHKLALLASIAFGTKVDFDGVELEGIEQVTLEDIRH
AADMGFRIKLLGVAQRSGRGLEQRMRPCLVPASSPLGQLEGGTNMVVIEGDQVGQVVLRG
AGAGEGPTASAVLSDIMDIARGDRISTFGQPASGLVTPIRAQSAVAAPYYLRMELEDKPG
ALAKVATVLGDSGVSIDRMRQYGHESSSAPVLIVTHKAARNAVDAALEALPKTGVVLGTP
VALRIEAV