Protein Info for Dshi_2045 in Dinoroseobacter shibae DFL-12

Annotation: thiamine pyrophosphate protein central region (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 592 TIGR03457: sulfoacetaldehyde acetyltransferase" amino acids 2 to 579 (578 residues), 918.5 bits, see alignment E=7.6e-281 PF02776: TPP_enzyme_N" amino acids 3 to 118 (116 residues), 110.4 bits, see alignment E=6.9e-36 PF00205: TPP_enzyme_M" amino acids 187 to 324 (138 residues), 120.6 bits, see alignment E=6e-39 PF02775: TPP_enzyme_C" amino acids 405 to 558 (154 residues), 103.2 bits, see alignment E=1.9e-33

Best Hits

Swiss-Prot: 79% identical to XSC_ROSNI: Sulfoacetaldehyde acetyltransferase (xsc) from Roseovarius nubinhibens (strain ATCC BAA-591 / DSM 15170 / ISM)

KEGG orthology group: None (inferred from 100% identity to dsh:Dshi_2045)

MetaCyc: 79% identical to sulfoacetaldehyde acetyltransferase (Roseovarius nubinhibens ISM)
Sulfoacetaldehyde acetyltransferase. [EC: 2.3.3.15]

Predicted SEED Role

"Sulfoacetaldehyde acetyltransferase (EC 2.3.3.15)" (EC 2.3.3.15)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.3.15

Use Curated BLAST to search for 2.3.3.15

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LPS9 at UniProt or InterPro

Protein Sequence (592 amino acids)

>Dshi_2045 thiamine pyrophosphate protein central region (RefSeq) (Dinoroseobacter shibae DFL-12)
MRMTTEEAFIKVLQRHGVDHAFGIIGSAMMPISDLFPEAGITFWDCAHEGSAGMMADGFT
RASGRMSMMIAQNGPGITNFVTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVAQMKLF
EDMVAYQEEVRDPSRMAEVLTRVISKAKTLSGPAQINIPRDFWTQVIDIEIPEPIEFERS
PGGEASVARAAALLSEAKNPVILNGAGVVLSEGGIAASKALAERLDAPVCVGYQHNDAFP
GGHPLFAGPLGYNGSKAAMELISEADVVLALGTRLNPFSTLPGYGMEYWPADAKIIQVDI
NSDRIGLTKKISVGIVGDAAKVARGILGQLAEDAGDAGRQERRDRIAQVKSRWAQQLSAM
DHEEDDPGTTWNARARAAKPDWMSPRMAWRAITAALPRDAIISSDIGNNCAIGNAYPDFD
APRKYLAPGLFGPCGYGLPAIVGAKIAQPDTPVVGFAGDGAFGIAVNELTAIGRGDWPAI
TQVVFRNYQWGAEKRNSTLWFDDNFVGTELDEEVSYAGIARACGLDGVVVRTMQELTDTL
ATAIKAQMTEGKTTLIEVLLNQELGEPFRRDAMKKPNKVAGVSKQDMMVEAG