Protein Info for Dshi_1956 in Dinoroseobacter shibae DFL-12

Annotation: NAD-dependent epimerase/dehydratase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 320 PF04321: RmlD_sub_bind" amino acids 1 to 254 (254 residues), 31.5 bits, see alignment E=4.1e-11 PF05368: NmrA" amino acids 3 to 70 (68 residues), 25.8 bits, see alignment E=2.8e-09 PF02719: Polysacc_synt_2" amino acids 3 to 118 (116 residues), 26.6 bits, see alignment E=1.3e-09 PF01370: Epimerase" amino acids 3 to 228 (226 residues), 87.3 bits, see alignment E=4.6e-28 PF01073: 3Beta_HSD" amino acids 4 to 251 (248 residues), 61.5 bits, see alignment E=2.9e-20 PF07993: NAD_binding_4" amino acids 5 to 177 (173 residues), 33.1 bits, see alignment E=1.3e-11 PF13460: NAD_binding_10" amino acids 7 to 173 (167 residues), 47.7 bits, see alignment E=6.9e-16

Best Hits

KEGG orthology group: None (inferred from 100% identity to dsh:Dshi_1956)

Predicted SEED Role

"NAD-dependent epimerase/dehydratase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LP15 at UniProt or InterPro

Protein Sequence (320 amino acids)

>Dshi_1956 NAD-dependent epimerase/dehydratase (RefSeq) (Dinoroseobacter shibae DFL-12)
MRILVTGPTGAIGQYVLEGLMQTDHDVRVLSLPDSLHRINFRDRIEIVMGELSDDISLAE
AVEGVDIIYHCALVGPPPAMSADHMMHVNAEGTRNLLRHAAGRVQRVVLCSSNNVYTPHR
APAMWPLLDDALREAHGNPQQVALGESLIAAEDAVFEAQARDGQDYAILRPTVVAGRKCP
FVEQMIISILQQPETIEVQRRMWDTMQWAHGSDIAAAALLVGEHPEAANQCFLVAGSEPI
TIYDVQAHIWDIMNVGKSDNPHRDIAERNNLGLCKFEPRKLRALGWAPRVDVKSCITEVL
GRLEFYSSASIKLPAHMVGD