Protein Info for Dshi_1809 in Dinoroseobacter shibae DFL-12

Annotation: excinuclease ABC, A subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 953 TIGR00630: excinuclease ABC subunit A" amino acids 6 to 929 (924 residues), 1464.6 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 133 to 239 (107 residues), 125.7 bits, see alignment E=1.8e-40 PF17755: UvrA_DNA-bind" amino acids 294 to 403 (110 residues), 138.2 bits, see alignment E=3.4e-44

Best Hits

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 72% identity to azc:AZC_2887)

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LMK6 at UniProt or InterPro

Protein Sequence (953 amino acids)

>Dshi_1809 excinuclease ABC, A subunit (RefSeq) (Dinoroseobacter shibae DFL-12)
MPELKKIEVRGAREHNLKSIDVDIPRDRLVVITGLSGSGKSSLAFDTIYAEGQRRYVESL
SAYARQFLDMMQKPDVDHISGLSPAISIEQKTTSKNPRSTVGTVTEIYDYMRLLFARVGT
PYSPATGLPIEAQQVQDMVDRVMAMEEGTRAYLLAPIIRDRKGEYRKEFLELRKQGFQRV
KVDGAFHDLDSPPTLDKKFRHDIDVVVDRIVVKEGIETRLADSFRTALDLADGIAILETA
PTEGEPERHTFSEKFACPVSGFTIPEIEPRLFSFNAPFGACPACDGLGVELFFDERLVVP
DATLTLANGALAPWRKGKSPYFLQTINAIAKHYEFDPKTPWKALPEKVQEVFLRGSGEEE
ITFRYDEGGRVYQVSRAFEGVIPNMERRYRETDSSWIREEFERYQNNRSCGTCGGYRLRP
EALAVKIAGLHVGEVVQMSIREAHDWCRTVPEHLSVQKNEIARAILKEIRERLGFLNNVG
LEYLTLSRNAGTLSGGESQRIRLASQIGSGLTGVLYVLDEPSIGLHQRDNDRLLTTLKNL
RDQGNTVIVVEHDEEAVREADYVFDIGPGAGVHGGQVVAHGTPAQIMANPASITGDYLAG
RREIPVPATRRKGNKKKVTVRKATGNNLQDLTVDFPLGKFVCVTGVSGGGKSTLTIETLF
KTASMRLNGARQTPAPCETIKGLEHLDKVIDIDQRPIGRTPRSNPATYTGAFTPIRDWFA
GLPEARTRGYKPGRFSFNVKGGRCEACQGDGVIKIEMHFLPDVYVECETCKGKRYNRETL
EVTFKGKSIADVLDMTVEDAQEFFKAVPSIREKMDALMRVGLGYIKVGQQATTLSGGEAQ
RVKLSKELAKRSTGRTLYILDEPTTGLHFEDVRKLLEVLHELVEQGNTVVVIEHNLDVIK
TADWLIDIGPEGGDGGGTLVATGTPEQVAEVAESHTGRYLKPMLAGAKRVAAE