Protein Info for Dshi_1366 in Dinoroseobacter shibae DFL-12
Annotation: aminotransferase class-III (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to BAUA_PSEAE: Beta-alanine--pyruvate aminotransferase (bauA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG orthology group: K00822, beta-alanine--pyruvate transaminase [EC: 2.6.1.18] (inferred from 100% identity to dsh:Dshi_1366)Predicted SEED Role
"Omega-amino acid--pyruvate aminotransferase (EC 2.6.1.18)" in subsystem Pyruvate Alanine Serine Interconversions (EC 2.6.1.18)
MetaCyc Pathways
- superpathway of coenzyme A biosynthesis II (plants) (8/10 steps found)
- β-alanine degradation II (2/2 steps found)
- β-alanine biosynthesis II (4/6 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Propanoate metabolism
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.18
Use Curated BLAST to search for 2.6.1.18
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A8LIZ4 at UniProt or InterPro
Protein Sequence (441 amino acids)
>Dshi_1366 aminotransferase class-III (RefSeq) (Dinoroseobacter shibae DFL-12) MALDAKSRPNDLSAFWMPFTANRQFKSNPRMFVAADGMYYTTAEGRQVLDGTAGLWCCNA GHKRPRIVEAIQAQAAELDYAPAFQMGHPRAFELANRLVEIAPDGMDHVFYTNSGSEAVE SALKIALAYHRARGEAGRTRLIGRERGYHGVNFGGISVGGIVNNRKHFGTLLTGVDHLPH THIPENQWSRGMPELGAHLADDLERIIALHGAETIAAVIVEPMAGSTGVLLPPKGYLQRL RKITQDHGIVLIFDEVITGFGRVGAAFGAQRFGVTPDMITCAKGLTNGVIPMGAVLCGSH IHDAFMQGPENLIELFHGYTYSGNPIASAAGLATLETYREDDLFARALDLEPYWQEALHS LKGARHVIDIRNLGLIGAIELEPISGHPTKRAFQAFLDAYDKGVLIRTTGDIIALSPPLI IETAQIDRIVETLGEVLAALD