Protein Info for Dshi_0795 in Dinoroseobacter shibae DFL-12

Annotation: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 212 TIGR01855: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit" amino acids 4 to 209 (206 residues), 199.7 bits, see alignment E=2.1e-63 PF00117: GATase" amino acids 44 to 208 (165 residues), 67.1 bits, see alignment E=1.7e-22 PF07722: Peptidase_C26" amino acids 74 to 194 (121 residues), 23.2 bits, see alignment E=5.3e-09

Best Hits

Swiss-Prot: 74% identical to HIS5_RUEPO: Imidazole glycerol phosphate synthase subunit HisH (hisH) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: K02501, glutamine amidotransferase [EC: 2.4.2.-] (inferred from 100% identity to dsh:Dshi_0795)

Predicted SEED Role

"Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)" in subsystem Histidine Biosynthesis (EC 2.4.2.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.-

Use Curated BLAST to search for 2.4.2.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LQZ7 at UniProt or InterPro

Protein Sequence (212 amino acids)

>Dshi_0795 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (RefSeq) (Dinoroseobacter shibae DFL-12)
MLTVLVDYDSGNLHSAEKAFERMAREVDGGEICVTSDPDLVARADRIVLPGDGAFPACRA
GLEGFAGLFEAIEEAVTARARPFLGICVGMQLMATTGREYEDTPGFGWIDGEVVKITPSD
PALKVPHMGWNDLVIDRPHPVLEGVATGDHAYFVHSYHMQVTDPATLLAHCDYGGPVTAV
VGRDTMVGAQFHPEKSQAAGLRMIANFLTWRP