Protein Info for Dshi_0728 in Dinoroseobacter shibae DFL-12

Annotation: NADH dehydrogenase (quinone) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 746 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 54 to 76 (23 residues), see Phobius details amino acids 84 to 103 (20 residues), see Phobius details amino acids 109 to 126 (18 residues), see Phobius details amino acids 138 to 160 (23 residues), see Phobius details amino acids 172 to 195 (24 residues), see Phobius details amino acids 207 to 234 (28 residues), see Phobius details amino acids 246 to 267 (22 residues), see Phobius details amino acids 274 to 292 (19 residues), see Phobius details amino acids 298 to 323 (26 residues), see Phobius details amino acids 344 to 364 (21 residues), see Phobius details amino acids 383 to 405 (23 residues), see Phobius details amino acids 425 to 447 (23 residues), see Phobius details amino acids 474 to 493 (20 residues), see Phobius details amino acids 542 to 561 (20 residues), see Phobius details amino acids 573 to 592 (20 residues), see Phobius details amino acids 599 to 618 (20 residues), see Phobius details amino acids 624 to 645 (22 residues), see Phobius details amino acids 657 to 678 (22 residues), see Phobius details amino acids 719 to 738 (20 residues), see Phobius details PF00662: Proton_antipo_N" amino acids 39 to 82 (44 residues), 38.7 bits, see alignment 1.5e-13 PF00361: Proton_antipo_M" amino acids 103 to 386 (284 residues), 197.4 bits, see alignment E=6.4e-62 PF13244: MbhD" amino acids 582 to 646 (65 residues), 50.9 bits, see alignment E=2.8e-17 PF20501: MbhE" amino acids 655 to 733 (79 residues), 70.6 bits, see alignment E=2e-23

Best Hits

KEGG orthology group: K05565, multicomponent Na+:H+ antiporter subunit A (inferred from 100% identity to dsh:Dshi_0728)

Predicted SEED Role

"Na(+) H(+) antiporter subunit A" in subsystem Sodium Hydrogen Antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LQT0 at UniProt or InterPro

Protein Sequence (746 amino acids)

>Dshi_0728 NADH dehydrogenase (quinone) (RefSeq) (Dinoroseobacter shibae DFL-12)
MPRLLTLVPAALMALTAAWFAQFIPQVASGEILTWSRPWIPGLDIEVAFLLDGLSMLFAL
MVTGIGAIIFLYSAVYFKGHPKLTMLLTLLFLFAVSMLGMVLADDMVTFFVFWEGTTITS
FLLVGFDHEKTKARDNALQALLVTGLGGLALLAGLILLGAEAGTFRISEMNAAAGAIQAS
AMYVPILVLVFIGAFTKSAQFPFHFWLPGAMAAPTPVSAYLHSATMVKAGIYLLARFTPA
LGGTEVWFWILTIVGAITMVWSSVLALKQTDLKLMLAYTTVMALGALTMMLGGGTRYAVM
TVSVFLVVHALYKAALFLTVGLIDKGTGTREVGQLGGLRREMPITFWIAILAALSMAGMA
PFVGFIGKELMYEAALGVETEPLFVVTAALLANANMVAAAALVAISPFFGARVAPPKSPA
DPTPWLWIGPALLAALGLAFGLVPALIDGPIITPVVQSILPGEEAVYLKLWHGVNLPLML
SILTFALGFALYYGRDKIRGSLQSANFTGGLDANDTYNLLLTSFKRFAAWSARTVQGGKM
TVYLRTAFAVLALLMWGAHLASRDAFNPPVEGIALIPMVICLLIAVSAAVVLTTGSRLYG
LTALGITGAGIAILFVFYSAIDVAITQLLVEMLVVIILAVALVKLPNMPREPNFRAGDAL
IATALGLGVAFVVASVLMQPFDPRINEFFNAASYPEALGRNVVNVILVDFRALDTLGEVA
VVLVAAISAAAALTAGLRAGRKEKEE