Protein Info for BT4703 in Bacteroides thetaiotaomicron VPI-5482

Annotation: chloromuconate cycloisomerase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_4703)

Predicted SEED Role

"O-succinylbenzoate synthase (EC 4.2.1.113)" (EC 4.2.1.113)

MetaCyc Pathways

superpathway of menaquinol-8 biosynthesis I (8/10 steps found)
superpathway of demethylmenaquinol-8 biosynthesis I (7/9 steps found)
2-carboxy-1,4-naphthoquinol biosynthesis (5/7 steps found)
superpathway of menaquinol-10 biosynthesis (7/10 steps found)
superpathway of menaquinol-11 biosynthesis (7/10 steps found)
superpathway of menaquinol-12 biosynthesis (7/10 steps found)
superpathway of menaquinol-13 biosynthesis (7/10 steps found)
superpathway of menaquinol-6 biosynthesis (7/10 steps found)
superpathway of menaquinol-7 biosynthesis (7/10 steps found)
superpathway of menaquinol-9 biosynthesis (7/10 steps found)
superpathway of demethylmenaquinol-6 biosynthesis I (6/9 steps found)
superpathway of demethylmenaquinol-9 biosynthesis (6/9 steps found)
superpathway of chorismate metabolism (38/59 steps found)
superpathway of phylloquinol biosynthesis (6/15 steps found)

KEGG Metabolic Maps

Ubiquinone and menaquinone biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.113

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q89YM8 at UniProt or InterPro

Protein Sequence (341 amino acids)

>BT4703 chloromuconate cycloisomerase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MDCKIDIIPRVLHFKQPAGTSRGTYTTRKVWYLHFTAPEFPNWVGIGECAPLPNLSCDDL
PDYEEVLAKICRQVENQGGKLDMEALCKYPSILFGLETAIRHFFEGSWALWDTPFSRGEA
GIPINGLIWMGDFNRMLAQIEKKMEAGFRCIKLKIGAINFEEELALLQHIRSHYSSKEIE
LRVDANGAFSPTDAMEKLKRLSELDLHSIEQPIRAGQWEEMARLTSESPLPIALDEELIG
YNTWEEKQRLLSAIRPQYIIIKPSLHGGLAGGEEWIAEAEKLNIGWWITSALESNIGLNA
IAQWCATFQNPLPQGLGTGLLFTDNVEMPLEIRKDCLWFCK