Protein Info for BT4680 in Bacteroides thetaiotaomicron VPI-5482

Annotation: DNA mismatch repair protein MutS (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 833 PF00488: MutS_V" amino acids 344 to 525 (182 residues), 111.1 bits, see alignment E=1e-35 PF20297: MSSS" amino acids 682 to 721 (40 residues), 42.6 bits, see alignment 5.8e-15 PF01713: Smr" amino acids 758 to 832 (75 residues), 75.5 bits, see alignment E=4.5e-25

Best Hits

KEGG orthology group: K07456, DNA mismatch repair protein MutS2 (inferred from 100% identity to bth:BT_4680)

Predicted SEED Role

"Recombination inhibitory protein MutS2" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q89YQ1 at UniProt or InterPro

Protein Sequence (833 amino acids)

>BT4680 DNA mismatch repair protein MutS (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MIYPQNFEQKIGFDQIRQLLKDKCLSTLGEERVSDMSFTEQFEEVEEKLNQVTEFVRIIQ
EEDGFPDQFFFDVRPSLKRVRIEGMYLDEQELFDLRRSLETIRDIVRFLHRNEEEEENDV
PYPSLKRLAGDIAVFPQLIGKIDGILNKYGKIKDNASSELARIRRELSSTMGSISRSLNS
ILRNAQSEGYVDKDVAPTMRDGRLVIPVAPGLKRKIKGIVHDESASGKTVFIEPAEVVEA
NNRIRELEGDERREIIRILTEFSNILRPSIPDILQSYEFLAEIDFIRAKSYFAIQTNSLK
PTVEKEQLLDWTMAVHPLLQLSLAKHGKKVVPLDIELNQKQRILIISGPNAGGKSVCLKT
VGLLQYMLQCGMLIPLHERSHAGMFSSIFIDIGDEQSIEDDLSTYSSHLTNMKIMMKSCN
ERSLILIDEFGGGTEPQIGGAIAEAVLKRFNQKGTFGVITTHYQNLKHFAEDHEGVVNGA
MLYDRHLMQALFQLQIGNPGSSFAVEIARKIGLPEDVIADASEIVGSEYINADKYLQDIV
RDKRYWEGKRQTIRQREKHMEDTIARYQTEMEELQKSRKEIIRQAKEEAERMLQESNARI
ENTIRTIKEAQAEKEKTRLVRQELNDFRTSLETMTSKEQEEKIARKMEKLKEKQERKKNK
KNEPKTAASQTAATPKVIPITVGENVKIKGQTSVGQVMEINGKNATVAFGSIKTTVKLDR
LERSNAAPKTEGIAKSTFVSSQTHDQMYEKKLNFKQDIDVRGMRGDEALQAITYFVDDAI
LVGMDRVRILHGTGTGILRTLIRQYLSTVPGVSHYADEHVQFGGAGITVVDFD