Protein Info for BT4656 in Bacteroides thetaiotaomicron VPI-5482

Annotation: N-acetylglucosamine-6-sulfatase precursor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 558 signal peptide" amino acids 1 to 44 (44 residues), see Phobius details PF00884: Sulfatase" amino acids 53 to 431 (379 residues), 189.6 bits, see alignment E=1.3e-59 PF01663: Phosphodiest" amino acids 77 to 376 (300 residues), 33.6 bits, see alignment E=5.3e-12 PF16347: SGSH_C" amino acids 379 to 534 (156 residues), 231 bits, see alignment E=1.1e-72

Best Hits

Swiss-Prot: 100% identical to GLCSF_BACTN: N-acetylglucosamine-6-O-sulfatase (BT_4656) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: None (inferred from 100% identity to bth:BT_4656)

Predicted SEED Role

"Mucin-desulfating sulfatase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q89YS5 at UniProt or InterPro

Protein Sequence (558 amino acids)

>BT4656 N-acetylglucosamine-6-sulfatase precursor (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MPATEKASAPHWSFLSSDVISIMKSNPSTLLLPLAALSLASCANPQKEETKRPNIIFMMT
DDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALSGPSRACILTGKFSHENGFT
DNASTFNGDQQTFPKLLQQAGYQTAMIGKWHLISEPQGFDHWSILSGQHEQGDYYDPDFW
EDGKHIVEKGYATDIITDKAINFLENRDKNKPFCMMYHQKAPHRNWMPAPRHLGIFNNTI
FPEPANLFDDYEGRGKAAREQDMSIEHTLTNDWDLKLLTREEMLKDTTNRLYSVYKRMPS
EVQDKWDSAYAQRIAEYRKGDLKGKALISWKYQQYMRDYLATVLAVDENIGRLLNYLEKI
GELDNTIIVYTSDQGFFLGEHGWFDKRFMYEECQRMPLIIRYPKAIKAGSTSSAISMNVD
FAPTFLDFAGVEVPSDIQGASLKPVLENEGKTPADWRKAAYYHYYEYPAEHSVKRHYGIR
TQDFKLIHFYNDIDEWEMYDMKADPREMNNIFGKAEYAKKQKELMQLLEETQKQYKDNDP
DEKETVLFKGDRRLMENR