Protein Info for BT4463 in Bacteroides thetaiotaomicron VPI-5482
Annotation: phosphatidate cytidylyltransferase (NCBI ptt file)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00981, phosphatidate cytidylyltransferase [EC: 2.7.7.41] (inferred from 100% identity to bth:BT_4463)Predicted SEED Role
"Phosphatidate cytidylyltransferase (EC 2.7.7.41)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.7.41)
MetaCyc Pathways
- phosphatidylglycerol biosynthesis I (5/6 steps found)
- phosphatidylglycerol biosynthesis II (5/6 steps found)
- CDP-diacylglycerol biosynthesis I (3/4 steps found)
- CDP-diacylglycerol biosynthesis II (3/4 steps found)
- CDP-diacylglycerol biosynthesis III (3/5 steps found)
- superpathway of phospholipid biosynthesis III (E. coli) (8/12 steps found)
- superpathway of cardiolipin biosynthesis (bacteria) (8/13 steps found)
- type I lipoteichoic acid biosynthesis (S. aureus) (3/17 steps found)
- superpathway of phospholipid biosynthesis II (plants) (8/28 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.7.7.41
Use Curated BLAST to search for 2.7.7.41
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q89ZB4 at UniProt or InterPro
Protein Sequence (318 amino acids)
>BT4463 phosphatidate cytidylyltransferase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482) MKQLLDKLFPTLSDELIIVITLIICLLVTASIALFLVKKLSPKTNISELVARTRSWWIMA AMFIGAVFISYDISYFFLAFLSFIAFRELYSVLGFREADRRALFWGILAIPIQYYLAYIA WYGAYIIFIPVVMFLLLPLRLVLKGDTHGITKSIALLQWILMLSVFGISHLAYLLSLPEL PGFNAGGRGLLMFLVFLTEINDIMQFVWGKLFGRHKILPKVSPNKTWEGFLGGVVSTTVI GYFLGFLTPLSTPNVILVSALIAIAGFAGDVVISAIKRDKGIKDMGDSIPGHGGVFDRID SLSYTAPVFFHLVYYIAY