Protein Info for BT4404 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1106 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details PF07660: STN" amino acids 61 to 110 (50 residues), 46.1 bits, see alignment (E = 8.2e-16) TIGR04056: TonB-linked outer membrane protein, SusC/RagA family" amino acids 122 to 1106 (985 residues), 744.3 bits, see alignment E=2.9e-227 PF13620: CarboxypepD_reg" amino acids 123 to 179 (57 residues), 47.3 bits, see alignment 5.5e-16 PF13715: CarbopepD_reg_2" amino acids 123 to 203 (81 residues), 68.3 bits, see alignment 1.2e-22 PF07715: Plug" amino acids 215 to 338 (124 residues), 65.5 bits, see alignment E=1.5e-21 TIGR04057: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region" amino acids 314 to 344 (31 residues), 57.5 bits, see alignment (E = 8.6e-20) PF00593: TonB_dep_Rec_b-barrel" amino acids 502 to 1011 (510 residues), 61.4 bits, see alignment E=3.8e-20

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_4404)

Predicted SEED Role

"SusC, outer membrane protein involved in starch binding"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q89ZH3 at UniProt or InterPro

Protein Sequence (1106 amino acids)

>BT4404 putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MLQIYEKRADNVVQKRVFLIFLGLLLMQTLAFAQSDSKITIQQKDITVVDALKTVERQSK
MSINYSDSELKGKKIADLNLEDVSVTTALDAILKGTGFSYQIQGNYIIVTEKKPAAAQSV
KDIKGKVTDENGEPLIGVNISVDGSSTGTITDFDGNFSIKSPGNARLKISYIGYATQLIA
VSNKDFYPITMKQDTEVLDEVVVTALGIKRAEKALSYNVQQIKSEDITGIKDANFINSLN
GKIAGVSINKSGSGVGGATRVVMRGAKSIEGDNNALYVVDGIPLFNTNMGNTDSGIMGEG
KAGTEGIADFNPEDIESISILSGPSAAALYGSSAANGVVLITTKKGQEGKLQISFSSSSE
FSKAYMVPEFQNTYGNKEGMFESWGDKLARPNSYDPKSDFFNTGTNFINSLTLSTGTKQN
QTFASVSSTNSKGIVPNNSYDRLNFTIRNTATFLDDKLQLDLGASYVKQEDKNMVSQGQY
WNPVISAYLFPRGEDFEDIKTFERYDQSRNIPIQYWPIADATYGSQNPYWTAYRNIATNE
KSRYMFNVGLSYKITDWMNLAGRYRMDDTHVQFERKVYATSDQKFAEGKKGLYDYSNYKD
RQEYADFMLNINKQFNDFNISANLGYSYSNYWSLARGYKGTLLGVTNLFAASNIDPSNGR
ISEDGGDSRVRNHAIFANVELGWRSMLYLTLTGRNDWNSRLVNTSEESFFYPSVGLSGII
SEMVKLPEFISYLKVRGSYTEVGSPVSQSGLTPGTVTTPIIGGALAPTGIYPFTDFKAER
TRSYELGLSVRLWNKLSAEVTYYKSNTYNQTFIGDLPEFSGYKQIYLQAGNVQNHGWEAS
LGYRDSFGDFSFSSNLTFSRNVNEIKEMVENYRTDMSPEPINVPEVRKDNGRVILKVGGS
INDIYANTFLKKDSQGYVEIKQDGSYGLEQGEPVFLGKTSPDFNLGWSNSLSYKGFGLSF
LINGRFGGVVTSSTQAILDRFGVSKASAEARDAGGVLLPGQGRVDAQSYYQLIGTGDYTT
SGYYVYSATNIRLQELTLSYRFPDLWFKNVLKDVTLSFIANNPWMLYSKAPHDPELTPSV
GTYGQGNDYFMQPSVRSFGFGIKFKL