Protein Info for BT4387 in Bacteroides thetaiotaomicron VPI-5482

Annotation: adenylate kinase (ATP-AMP transphosphatase) (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13671: AAA_33
  • amino acids 4 to 144 (141 residues), 30.9 bits, E=6.3e-11
• PF13238: AAA_18
  • amino acids 4 to 140 (137 residues), 37.1 bits, E=9e-13
• PF00406: ADK
  • amino acids 6 to 164 (159 residues), 186.4 bits, E=6.9e-59
• PF13207: AAA_17
  • amino acids 7 to 143 (137 residues), 125.1 bits, E=5.2e-40

Best Hits

Swiss-Prot: 100% identical to KAD_BACTN: Adenylate kinase (adk) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K00939, adenylate kinase [EC: 2.7.4.3] (inferred from 100% identity to bth:BT_4387)

Predicted SEED Role

"Adenylate kinase (EC 2.7.4.3)" in subsystem Purine conversions (EC 2.7.4.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• adenosine ribonucleotides de novo biosynthesis (3/3 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.3

Sequence Analysis Tools

See Q89ZJ0 at UniProt or InterPro

Protein Sequence (189 amino acids)

>BT4387 adenylate kinase (ATP-AMP transphosphatase) (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTELGKTAKGYIDQGQLI
PDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAERGQDVSVMLDLEVPEDE
LMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTSPLIDWYKNEKKYQHINGLGTMDGIFA
DICEAVDKL