Protein Info for BT4173 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative rhamnogalacturonan acetylesterase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 524 PF00657: Lipase_GDSL" amino acids 46 to 259 (214 residues), 54.4 bits, see alignment E=2e-18 amino acids 297 to 506 (210 residues), 29 bits, see alignment E=1.2e-10 PF13472: Lipase_GDSL_2" amino acids 49 to 255 (207 residues), 49.6 bits, see alignment E=7.1e-17 amino acids 300 to 501 (202 residues), 50.3 bits, see alignment E=4.4e-17

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_4173)

Predicted SEED Role

"rhamnogalacturonan acetylesterase" in subsystem L-rhamnose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A048 at UniProt or InterPro

Protein Sequence (524 amino acids)

>BT4173 putative rhamnogalacturonan acetylesterase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MQAQNNIASPMKDVNQVVDNTLDSLNKARTARPVAGASRKGNNPVLFLVGNSTMRTGTLG
NGNNGQWGWGYYAGDYFDSNRITVENHALGGTSSRTFYNRLWPDVIKGVQAGDWVIIELG
HNDNGPYDSGRARASIPGIGKDSLNVTIKETGVKETVYTYGEYMRRFINDVKAKGAHPIL
FSLTPRNAWADKDSTIITRVNKTFGLWAKQVAEEQNVPFIDLNDISARKFEKFGKNKVKY
MFYIDRIHTSAFGAKVNAESAADGIRACEGLELAKYLKPVEKDEATGSSRKEGRPVLFTI
GDSTVKNKDNDKNGMWGWGSVIADEFDLNKISVENCAMAGRSARTFLDEGRWDKVYHALQ
PGDFVLIQFGHNDAGEINTGKARAELPGSGEESKVFLMEKTGKYQVIYTFGWYLRKFIMD
VQEKGAIPIVLSHTPRNKWKDGKIERNTASFGKWTREAAEATGAYFIDLNKISADKLEKK
GIKKAADYYNNDHTHTSLKGAHMNAKSIADGLKMADCPLKQYLK