Protein Info for BT4121 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1142 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details TIGR04056: TonB-linked outer membrane protein, SusC/RagA family" amino acids 37 to 1142 (1106 residues), 902.7 bits, see alignment E=3.9e-275 PF13620: CarboxypepD_reg" amino acids 39 to 100 (62 residues), 40.1 bits, see alignment 6.1e-14 PF13715: CarbopepD_reg_2" amino acids 39 to 118 (80 residues), 61.8 bits, see alignment 8e-21 PF07715: Plug" amino acids 126 to 247 (122 residues), 72.3 bits, see alignment E=6.6e-24 TIGR04057: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region" amino acids 224 to 253 (30 residues), 51.6 bits, see alignment (E = 6.3e-18)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_4121)

Predicted SEED Role

"TonB family protein / TonB-dependent receptor" in subsystem Iron acquisition in Vibrio or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A0A0 at UniProt or InterPro

Protein Sequence (1142 amino acids)

>BT4121 putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MNKHIVLMKFKSSSFIKKVGVLLCFVAFALSANAQTRKVTGQIVDESGQPIIGATIRLQD
ATTGTITDIDGHFSLNVPDGKKVVISYIGYLKQVILPKGDTLKVILQEDNQKLDEVVVVG
YGSMKQKNITGSVSTISAEELEDLPVSNLSEALQGMVNGLNVQLGSSRPGTNANEVYIRQ
NRTFTGISKDGGNSTPLIIIDDVIQLGTNGQPSMEQFNMLDPSEVESITVLRDASAAIYG
SRAANGAILVKTKRGKKGVPVISYSGKFAVNDAVSHSKVLKGSAYGRFYNALAIGSNKAS
GYDDLDVLYSDMELAEMDNLNYDWLDKAGWKSAFQQTHTLNVTGGSERATYYAGATYFDQ
GANLGDQSYKRYTYRAGVDVRLTNDIKLSATVAGNEGKSDQIYTKGARFKLYGMSGSTEK
SDYSALHHMPNHMPWSVTLSDENGQDQEYWLGPIENTYSSPSFNRDYVTSWNYFALNNSG
SFSKNRSNSWNADISLTYEVPFVKGLSLRATYSSSHSSEATEQASFPYELAYVGGRMPAD
QHLVYTIPSSSFKTAIFDKNSTLSFKDKQAERRQMNFYVNYDRTFGQHSISAMASIERYE
SFYDSRDIEYADLAHDISDTYLGVGGPSIVGPDGKSALASDNTVTLKGESGSLSYLGRVA
YSYADRYMLQFIFRSDASTKFAPENYWGFFPGISAGWIMSEESWFKRSLPWFEFLKVRAS
WGRTGRDNIKMWKWKEQYKMDLKGMQFGAESGKPGTSLIPQSSPNRNVKWDVSDKFNLGF
DTRFFDGRLSAVFDFYYDINDNILNQFMASQPGIPVYAGGSYAEENFGRVDTYGGELSLT
WRDKVGQVNYNIGMDFGLNGSRVKEWVPGLRYNKYPSSSSWEEGMSTYLPVWGFKVWKGT
SNGDGILRTQDDINRYWSYLESYTPEGGQTKYLDKTSKDDLRPGMLAYQDLGGEMVNGVQ
QGPNGQIVLEQDYGKLCEKNKTYNVSTRLGASWKGLAISANIATSWGGVRFIDRASMGGN
KSTMIWAPDSFWGDMFDEMYNPNGKYPNLGTESLISSSAIANSDFWMISTFRCYIRNLSV
SYTLPKKWIAPLKMSAVRLNLTGNNLWDLYNPYPDHYRNMYDASSTDYPTLRTWSLGVNV
TF