Protein Info for BT4090 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1026 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR04056: TonB-linked outer membrane protein, SusC/RagA family" amino acids 24 to 1026 (1003 residues), 952.6 bits, see alignment E=3.3e-290 PF13620: CarboxypepD_reg" amino acids 24 to 89 (66 residues), 34.2 bits, see alignment 4.1e-12 PF13715: CarbopepD_reg_2" amino acids 25 to 104 (80 residues), 67.5 bits, see alignment 1.3e-22 PF07715: Plug" amino acids 114 to 222 (109 residues), 63.8 bits, see alignment E=3e-21 TIGR04057: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region" amino acids 198 to 228 (31 residues), 54.4 bits, see alignment (E = 8.4e-19)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_4090)

Predicted SEED Role

"TonB family protein / TonB-dependent receptor" in subsystem Iron acquisition in Vibrio or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A0D1 at UniProt or InterPro

Protein Sequence (1026 amino acids)

>BT4090 putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKRLLLILVCISLFISAFGQSFVLKGIVSSADGELLPGVNVKIQGTTVGTITDIDGNFQL
NVNKGAVLEFSYIGFKKQSIKVNSQQMLNVELAPDQTNLDEVVVVGYGKAKRITLTGAVS
GIQAREIRNVPTSSVQNALTGKLPGFFSQQQSGQPGKDASDFFIRGVSSLNNDGNKPLIM
VDDMQYTYEQLSQINVNEIESISILKDASTTAIYGIKGANGVLVVKTRRGEQGKPKINVR
LETGMQTPVRTPKFLNAYESLQLVKEAHTNDGTLSDFPYTEDDMIAFRDHTDPYGHPDVN
WYDEIFKKMAFQENINVDVSGGSKKLRYFVSAGYFTQNGLVKDFGGNSGDGVNPNYSYRR
FNYRTNLDFDVTDNFNMRLDVSSRFMDINEPYNMNVTGELYDFSKMHPYSAPLLNPDGSF
AYLYDTQDRKPTLNARLANEGYKRTRRNDNNILYGATWKMDFLTPGLAADFQLAYSSSDE
NYRAVMRTRYPTYHYDSATGLYNINPNGVYDYEQYFVYNSTDKAIKDLNIKASLKYAHVF
NNAHDVNVMFLYNRQSTTNEKDAAVPNNFEGYTMQLGYKYKNKYLVDLNMAYNGTDRFGK
DNNFGFFPALAIGYAISQEDFFKNVDWLGRNVQLLKFRTSYGLVGSDVASGDRYLYRQVY
KTGDSYTFGEGNNFGVSGIKEGDLGNLNVTWEKARKFNVGVDMNLFDKFSLTFDWFIDKR
YDQLVTRNDIPDILGIGLSPENVAETTNKGFDGQIGYQDRFGNFNFNTNFVFGYAKNRVD
YKAEAQQKYEWLRETGRQIGQPFGYHWIGYYTPEDIEKINSGAADAPAKPDIAVQAGDLK
YADLNGDGTINDFDKRAIGKPNLPTTTLGWTIGGSWKGFSISVLFQGSFDYSFAINGTGI
ESGKSQFQPLHQKRWTQERYENGESIEFPRLTMQDGTINSASAYNSDFWLINAWYIRLKT
VDLGYQLPKTALPKFLDNVRFYVNAYNLLTFTGYDKYQQDPEIKTNTAGDAYMNQRVINF
GVQLGF