Protein Info for BT4045 in Bacteroides thetaiotaomicron VPI-5482

Annotation: aminoacyl-histidine dipeptidase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 485 TIGR01893: Xaa-His dipeptidase" amino acids 8 to 481 (474 residues), 589.6 bits, see alignment E=2.2e-181 PF01546: Peptidase_M20" amino acids 72 to 480 (409 residues), 55.2 bits, see alignment E=9.3e-19 PF07687: M20_dimer" amino acids 207 to 291 (85 residues), 40.4 bits, see alignment E=2.5e-14

Best Hits

KEGG orthology group: K01270, aminoacylhistidine dipeptidase [EC: 3.4.13.3] (inferred from 100% identity to bth:BT_4045)

Predicted SEED Role

"Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3)" (EC 3.4.13.3)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.13.3

Use Curated BLAST to search for 3.4.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A0H6 at UniProt or InterPro

Protein Sequence (485 amino acids)

>BT4045 aminoacyl-histidine dipeptidase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MSTILSLAPQNVWKHFYSLTQIPRPSGHMEKVTEFLINFGKGLGLESFVDEAGNVIIRKP
ATPGMENRKGVILQAHMDMVPQKNNDTVHDFEKDPIETYIDGDWVKAKGTTLGADNGLGV
AAIMAVLEANDLKHGPLEALITKDEETGMYGAFGLKPGTVNGEILLNLDSEDEGELYIGC
AGGMDVTATLEYKEVAPEEGDVAVKVSLKGLRGGHSGLEINEGRANANKLLVRFVREAVA
SYEARLVSWDGGNMRNAIPREACAVLAIPAENEEELLGLVKYCEDLFNEEFSAIETPISF
TAERVELPAGEVPEEIQDNLIDAIFACQNGVTRMIPTVPDTVETSSNLAIITIGGGKAEI
KILARSSSDSMKEYLTTSLESCFSMAGMKVEMTGGYSGWQPNVESPILHAMKESYKQQFG
VEPAVKVIHAGLECGIIGAIIPGLDMISFGPTLRSPHSPDERALIPTVQKFYDFLVATLA
QTPTK