Protein Info for BT3999 in Bacteroides thetaiotaomicron VPI-5482

Annotation: membrane-bound lytic murein transglycosylase D presursor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 431 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF01464: SLT" amino acids 133 to 238 (106 residues), 95.6 bits, see alignment E=1.5e-31 PF01476: LysM" amino acids 388 to 429 (42 residues), 52.8 bits, see alignment 3.1e-18

Best Hits

KEGG orthology group: K08307, membrane-bound lytic murein transglycosylase D [EC: 3.2.1.-] (inferred from 100% identity to bth:BT_3999)

Predicted SEED Role

"Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-)" (EC 3.2.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.-

Use Curated BLAST to search for 3.2.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A0M2 at UniProt or InterPro

Protein Sequence (431 amino acids)

>BT3999 membrane-bound lytic murein transglycosylase D presursor (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKKLENYCSIIFLFLLATTQVKAQSVDVVIRENGTERKESIDLPKSMTYPLDSLLNDWKA
KNYIDLGKDCSTAEVNPLFSDSVYIDRLSRIPAVMEMPYNDIVRKFIDMYAGRLRNQVSF
MLSACNFYMPIFEEALDAYGLPLELKYLPIIESALNPSAVSRAGASGLWQFMIGTGKIYG
LESNSLIDERRDPIKATWAAARYLKEMYDIYGDWNLVIAAYNCGPGTINKAIRRAGGETD
YWKIYNLLPKETRGYVPAFIAANYVMTYYCDHNICPMETNIPASTDTVQVTKNLHFEQIA
ELCNVPLEEVKSLNPQYKKQVIPGTTKPCTLRLPQGAISTFIDKQDTIYAHRADELFRNR
KTVAVKEVTPTTRRQTSAVAGKGKLTYYKIKSGDTLSSIAEKLGVRVKDIQQWNGMSNTR
IAAGKQLKIYK