Protein Info for BT3800 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1333 transmembrane" amino acids 759 to 779 (21 residues), see Phobius details PF07494: Reg_prop" amino acids 4 to 27 (24 residues), 24 bits, see alignment (E = 9.4e-09) amino acids 473 to 491 (19 residues), 17.2 bits, see alignment (E = 1.6e-06) amino acids 560 to 582 (23 residues), 21.1 bits, see alignment (E = 8.5e-08) PF07495: Y_Y_Y" amino acids 692 to 752 (61 residues), 51.7 bits, see alignment 2.4e-17 PF00512: HisKA" amino acids 814 to 879 (66 residues), 43.1 bits, see alignment 1.3e-14 PF02518: HATPase_c" amino acids 926 to 1038 (113 residues), 70.1 bits, see alignment E=7.3e-23 PF00072: Response_reg" amino acids 1087 to 1196 (110 residues), 87 bits, see alignment E=3.6e-28 PF12833: HTH_18" amino acids 1251 to 1328 (78 residues), 63.9 bits, see alignment 4.9e-21

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3800)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A167 at UniProt or InterPro

Protein Sequence (1333 amino acids)

>BT3800 two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MRDGLADNTIPCIYKDEDGFMWFGTDNGLSRYDGKTIQNFKPANTYVSIAAIVRLSDDFL
GIVSDGYLYYFNRKRETFLPIHTESDTAIGVFNVLPADDSSFWGISGNRLILCQWEIQQG
KEEEKTAVRVRIQKTFQLLEEKGEVFSSLCYHEKAGSGIWLTTNRGNLILFHPDTPGAYQ
KIPLTDGKTLQVTSILNRDGVVWVSTIGKGIVRYHTKSGHMDRISYGGTGKENLLSHTDV
YQTIFIGNNRYLAVTWGGYTLLMPDEKQPEELTSEIYNNTHTQIYRNLETRMISACYDPN
GLLWIGTNGGGVMYSDLRSQFYDRYYQDRHNEICDILMDDSHRLWLATYHKGIMRSDIPY
AKGKKLSFSKVDTGSGKSEETMLCALKDVDGNLWFGNINGTLTVYHVRTGRFVIHSLLVD
GVANRASVWALYMDDKNRLYVGTEDGLLLYNRQTGICVKLSAAHYLNEKRQPFIRAIAQT
KDGTIWLGTSNMGVCRVVESASGGISVENGYEQKMNMEYRSVRSLLASSDGNLYIGYTDG
FAILSPRQNTISARYTTNDGLCSNFIGCIAEDSEGHIWLGSNSGISRYGRRQHLFYNYYI
AGSNRSALFSDKTLFFGNNQSLTYFNPEDINAYPTNGRVLITGLEVDNHPVGTGEKINNQ
IILNQFIPFTDRIVLDNDNKDFSLTFNNLSYSDEQQKYNYRLLPYQGNWLISDEGEKASY
TNLPAGEYVFEVKNIHPNGQTGAVTSLKIIILPHWSQTFAFRLFVSLLLLGGVAYGVRLI
RLRQKRMEHEMQMKHELLTVSMEREKERQIRVERENFFTGVAHELRTPLTLILAPLQELM
KQCNPLDDFYKKLQVMYKNAASLHTLVDQLLYVQKIEAGMVRLQLSETDLVQLVCNVSEP
FRQMAEIKGLQFDIDLPEGKFLYWVDEGKIASAVQNLLSNAFKYTPSGGRVLLSVSHLMK
SGQGYCRITVSDTGAGIPEWLQKHAFESFVTGDNVPEMSTKAGIGLHIVKNTMDLHHGLV
TLKSVPDEGSIFALYIPEGKEHFAKDSYELIDSHQGKTKQNEELKPEPFLPIPENKIQET
AAKKSLLIIEDNEDVREYIRSLFISRYAVSEACNGEEGVRIAKEQLPDLIISDVMMPVKD
GFTCCREIRMQQETAHIPILILTARAEDADILQGCNSGADDYMMKPFNPEILKTKVDNLI
LQRERLKRIYTKALMLKQESEEGEKEDAFLQQLIHIIEANLSNADFNVKMLAEQLNMSQP
TLYRKVKQRSDLSVIDMIRSIRISKAATLILENRYSIQEISEMVGYSDTRTLRKHFMEQF
GVSPSKYMGSTDR