Protein Info for BT3633 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 945 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF13620: CarboxypepD_reg" amino acids 29 to 103 (75 residues), 54.5 bits, see alignment E=2.5e-18 PF13715: CarbopepD_reg_2" amino acids 30 to 116 (87 residues), 77.2 bits, see alignment E=1.6e-25 PF07715: Plug" amino acids 130 to 234 (105 residues), 37.1 bits, see alignment E=7.7e-13 PF00593: TonB_dep_Rec_b-barrel" amino acids 295 to 912 (618 residues), 58.2 bits, see alignment E=2.9e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3633)

Predicted SEED Role

"TonB-dependent receptor; Outer membrane receptor for ferrienterochelin and colicins"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A1M6 at UniProt or InterPro

Protein Sequence (945 amino acids)

>BT3633 putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MRFLTLKIMLCLLLSLIISRIEANTNNYSISGRISDERTGSPLPGASILIKGTYLWAVSD
QKGEFTIQGIQEGKYQLEVSFLGYVPATVPVNVNNSIKGLKIQLKENTLALNDVIVTAQA
PKSELNTTLNIGSNALEHLQISNVSDISALLPGGKTKVPDLTSNNIFSLRDGGSSAGNAA
FGTAIEVDGVRIGNNSSFGNMTGIDTRSISVADIESVEVITGVPSAEYGDLNSGMVKIHT
KKGKTPWNVLLSINPRTEQVSFSKGLDLGNDKGIVNISGEWIKATQKLNSPYTSYTRRGF
SAGYSNTFRKVLRFDIGLTGNIGGMNTKDDPDAYTGEYTKVRDNVFRANTSLAWLLNKSW
ITNLKLDASVYYNDNKSHAHTPYSYASEQPAVHAEQEGYFIAGKLPYHFFADQIVDSKEL
DYAASLKYEWNRRFKNVTSNLKAGVQWKGTGNVGDGEYYQNPSLAPNGYRPRSYSAYPYM
HNVSLYAEESLSVAVGSTMLRLMAGLRWENLFISGTQYDKLNTLSPRFNARWQLNENIAI
RGGWGVTEKLPSYYVLYPRQEYRDIQTFGVSYNNNESAYVYYSQPYTLLHNEKLRWQKNQ
NAEIGVDINVARTRISLVGYFNRTKMPYKYTSTYTPFAYNVLQLPEGFELSANPQITVDN
QTGMGYIRDDEDSYWTPLDVKVKDQTFVRSTSPDNGPDITRRGAEMIIDFPEITPLRTQF
RVDAAYTYSKYIDNSLSYYYQNGWSHTTLANRSYQYVGIYANGDNSSTTANGKRTHSLDA
NITAITRIPKARLIISCKLEASLIKRSQNLSEYNGTSYAFNVSENSNEKTGGSIYDGNSY
TAIYPVAYLDLNNEVHPFTAAEAENPDFAHLIRKSGNAYTFAADGYDPYFSANISITKEI
GDHVSLSFNAINFTNSRAYVKSYATGTSAIFTPNFYYGLTCRIKL