Protein Info for BT3613 in Bacteroides thetaiotaomicron VPI-5482

Annotation: LacI family transcriptional regulator (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 347 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00356: LacI" amino acids 8 to 53 (46 residues), 39.4 bits, see alignment 8.2e-14 PF13407: Peripla_BP_4" amino acids 67 to 317 (251 residues), 71.1 bits, see alignment E=2.2e-23 PF00532: Peripla_BP_1" amino acids 67 to 327 (261 residues), 111.7 bits, see alignment E=9.7e-36 PF13377: Peripla_BP_3" amino acids 176 to 335 (160 residues), 119.5 bits, see alignment E=3.4e-38

Best Hits

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 100% identity to bth:BT_3613)

Predicted SEED Role

"LacI family transcriptional regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A1P6 at UniProt or InterPro

Protein Sequence (347 amino acids)

>BT3613 LacI family transcriptional regulator (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MENRKHTSLKDLAQALGVSIPTVSRALKDSPEISRELCAKAKKLAKEMNYRPNPFAMSLR
KNAPRIIGVIVPDIVTHFFASILNGIENMAIDNGYFVIITTSHESFEHEKRNIENLVNMR
VEGIIACLSQETTDFSHFAALKEINMPLILFDRVCLTDQFSSVIADGAQSAQMATQHLLD
NGSKRVAFIGGANHLDIVKRRKHGYLEALRDNRIPIEKELVVCRKIDYEEGQIATETLLS
LPQPPDAILAMNDTLAFAAMEVIKRHGLRIPDDIAIIGYTDEQHANYVEPKLSAVSHQTY
KMGETACQLLIDQIKGDRTVKQVVIPTHLQIRESSIKENNKKNAVST