Protein Info for BT3581 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative dehydrogenases and relate proteins (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 2 to 26 (25 residues), 17 bits, see alignment (E = 3e-07) PF01408: GFO_IDH_MocA" amino acids 42 to 165 (124 residues), 59.9 bits, see alignment E=5.9e-20 PF19051: GFO_IDH_MocA_C2" amino acids 208 to 273 (66 residues), 28.6 bits, see alignment E=1.5e-10 amino acids 342 to 444 (103 residues), 23.3 bits, see alignment E=6.2e-09 PF02894: GFO_IDH_MocA_C" amino acids 233 to 413 (181 residues), 28.8 bits, see alignment E=1.6e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3581)

Predicted SEED Role

"Myo-inositol 2-dehydrogenase (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A1S8 at UniProt or InterPro

Protein Sequence (447 amino acids)

>BT3581 putative dehydrogenases and relate proteins (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MTTRRDFIKKTVAGTAALSLGSIIPGFGSNSYQEILGANEKIRIGVIGVNSRGNALAQGF
AKMKGCEVTYLCDVDSRALERCQADIHKISGRTPKGEKDIRKMLESDDFEAVVIATPDHW
HGKAAIMAMQAGKHVYLEKPTSHNPAENEMLVRATLKYNRIVQVGNQRRSWPNVIKAIEE
IKSGAIGKVRYAKSWYVNNRPSIGTGKVVPVPDYLDWDLWQGPAPRVPNFKDNYIHYNWH
WFWNWGTGEALNNGTHFVDILRWGLGVDYPTKVDSVGGRYRFQDDWQTPDTQLITFQFGD
EASCSWEGRSCNSTPVDGYGVGTAFYGETGTLFISGGNEYKITDLQGKVIKDVKSNLKFE
TGNLLNPSEKLDAYHFENWFDAIRKGGKLNSGIVDACISTQLVQLGNIAQRVGHSLDIDP
GSGRILNDLEANKLWGREYEKGWEIRV