Protein Info for BT3546 in Bacteroides thetaiotaomicron VPI-5482

Annotation: glutaminase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 965 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF16334: DUF4964" amino acids 17 to 101 (85 residues), 115.2 bits, see alignment E=1.4e-37 PF17168: DUF5127" amino acids 409 to 624 (216 residues), 168.7 bits, see alignment E=2.7e-53 PF16335: GtaA_6_Hairpin" amino acids 630 to 961 (332 residues), 414.3 bits, see alignment E=6.7e-128

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3546)

Predicted SEED Role

"Glutaminase A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A1W2 at UniProt or InterPro

Protein Sequence (965 amino acids)

>BT3546 glutaminase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MRIYKTLMNKTFIYLLIAVLAACKSTPYSDETTKSDLRAPAYPLLTLHPHVKLWSMTDEL
NKQNMTFGGSTQLPFVGFLRVDGAMYRFMGSKELPMQAIAPMALDHEKWEGKFTSLVPDE
GWEQPDFDDKYWQLSEGAFGTPGMWEARTQWTSSNIWVRREVEVDPYLLEHKKIYLRYSH
DDVFQLYINGKQLVNTGYDWGANFKVEVPDSILQTMKSGKALIAAHCENRVGGGLVDFGL
FAEEPTMPVEKVAPISYEKEWTGRYTMEQPQENWEAKEFDDTTWTEGQAAFGTDDQRNVH
TPWFSPNIWVRRELTFDPALVKNKQLYLRYSHDDVFQLYVNGMQLVSTGYEWKSDLRVNI
PDSIAETMKDGKAVIAAHCENRMGGALVDFGLYAELREAEQTSVDVQATQTHYTFECGDV
ELKLSFTAPYLLDDLETLARPVNYISYQAKALDGKEHDVAVYFEIDPHKAFRAGQSTQIY
EKDGLALMKTGQENQKLWVDKEKDGRSWGYFYLGTKDDVTCAQGDAAEMRAYFMKEGDLK
QMRKSAEKRYAAFAQKLDMNSDFPQHLTAAFDGLYTMAYFGEDLRPYWNKDGKSSIEDLY
ADAEKDYKEVMAKCYAFDRQLMADAYLAGGKEYAELCALAYRQSVSAFQMSEDSDGELLY
FTPQVGPVDEYYPASPLYLRYNPDLVKAMLNPFFYYSESGKWGKPFPPHDLGGYPIVNGQ
TIGGDMPVEEAGNGLIMTAAIAKMEKNASYAEKHWKTLTQWAEYLLENGTDTGDQLTTDN
FAGNCPHHANLSAKGVLGIAAYARLAEMLNKKEEAEKYMNAAGEMAKEWEMAAYAGDHYR
LAFDQPDSWGMKYNLVWDRLLGLNLFPERVIQKETDFYLTKMNEFGCPLDSRHSYTKVDW
TVWTASLSADRMQFRKLMLPLHKFMNETTDRTPMADLINTDGKTIVGFTGRTVVGAYFIR
LLEKE