Protein Info for BT3318 in Bacteroides thetaiotaomicron VPI-5482

Annotation: signal peptidase I (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 312 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF10502: Peptidase_S26" amino acids 7 to 113 (107 residues), 60.6 bits, see alignment E=9.8e-21 amino acids 254 to 290 (37 residues), 28.1 bits, see alignment 9e-11 TIGR02227: signal peptidase I" amino acids 8 to 114 (107 residues), 55.5 bits, see alignment E=3.1e-19

Best Hits

KEGG orthology group: K03100, signal peptidase I [EC: 3.4.21.89] (inferred from 100% identity to bth:BT_3318)

Predicted SEED Role

"Signal peptidase I (EC 3.4.21.89)" in subsystem Signal peptidase (EC 3.4.21.89)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.89

Use Curated BLAST to search for 3.4.21.89

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A2I7 at UniProt or InterPro

Protein Sequence (312 amino acids)

>BT3318 signal peptidase I (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MNIRKFKWIFAFAGAIAVVLLLRGFAFTSCLIPSTGMENSLFQGERILVNKWSYGLRVPL
MSLFSYHRWCERSVRQQDVVVFNNPAAIGQPTIDRREIYISRCIGTPGDTLLVDSLFSVS
SPEAQLNPDKKRLYTYPAAKEQLITSLMQTLSITNDGLMGSNDSTHVRSFSRYEYYLLEQ
AISDQNWIQPLTEKSEKELKPLIVPGKGKALRVYPWNITLLRNTLVMHEGKQAEIKNDTL
YIDGKPTQHCFFTKDYYWMASNNSVNLSDSRLFGFVPQDHIIGKASLIWFSKEKGTGIFD
GYRWNRFFQSVK