Protein Info for BT3115 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydraogenase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1106 transmembrane" amino acids 305 to 324 (20 residues), see Phobius details PF01619: Pro_dh" amino acids 93 to 391 (299 residues), 195.2 bits, see alignment E=1.8e-61 PF00171: Aldedh" amino acids 502 to 933 (432 residues), 360.2 bits, see alignment E=1.4e-111

Best Hits

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 100% identity to bth:BT_3115)

Predicted SEED Role

No annotation

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A340 at UniProt or InterPro

Protein Sequence (1106 amino acids)

>BT3115 putative proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydraogenase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MVQRPQDKKFLVKMLDESSQIRDRRILAKRIKTLLDQYGVPEFLNKRDSFLFKMYQAFGH
HFDFIAIPIIKKRLRMNTSQVIINEARPQLTKHLAIRAKEKIGQNVNLLGEVVLGNGEAD
HRYHHYLKALESPDINYISVKISGIYAQTHALNYEESFPELISRMSALYQKAIDFPYTDE
EGVRRSKFINLDMEEYKDTHFTLRLFKTVLSLPQFKNYSAGIVVQAYLPDAYDFQTELIE
FAKARVAEGGAPIKMRLVKGCNLEMETVISSLRGWPNPIRPSKEEVDANYLHLLERALMP
ENARVLHLGVASHNLFSIAYAYLLAQKYGTAEYMTFEMLEGMANHLWRAQSMLGNRVILY
TPVVKNEHFLNAVSYLVRRMDENTAPDNFLTHSFNLRPNTKEWDFLAKQFEDAYAMKDQL
SHVSPRTQNRNLPYTPVPPADVLKNEPDTDFDLPQNQEWVRSIFSKWKKDGTEQPEIIPL
QIGAETVVCESRYPYTDRCQDDEVCICEMSQADSAQVEKIIEIAEADPAGWRKTTLEERH
RIMYEAANRLADMRGDLIGCMCAVTGKTVIEGDVEVSEAVDYARFYTTAMKKFAALDDVE
MKPKGTILVISPWNFPCAIPVGGIVAGLAGGNTVILKPATVAAPVAWMFAKAFWDAGVPK
EALQVIITRREALKVLTTAPAIKHIILTGGTDTAQNIAKANPTTPLSAETGGKNVIILTA
SGDRDHAIMNIVTSAFGNAGQKCSACSLLLVERSVYEDENFRSKLKDAATSLKTGSVWNA
GNIVGPMITNKNDKLLQAFNLEPGESWLVPPRFIDRREYILAPTVKWGVKPESFSFRTEL
FGPLLSVACIENLEEGIRLVNGLDYGLTSGLQSLDEKEQKLWKNSVMAGNLYINRGITGA
IVNRQPFGGMKLSAFGGGIKAGGPNYCTCFLEITDKPDSRTDYRQSYAKAYQEEFSKPRD
VNRLYGEQNLFRYLPLKNMILRLFPKDTDEEATMIAHAARICRTPLTISFGPTDDRSSRL
AGLGCTLRKESLEDFLKELPEYERVRTCSPDIPDVMYERAAETNKYIATAPPVKQGRIEL
IHYIKEQSIAFEYHRYGSISEVPPCE