Protein Info for BT2880 in Bacteroides thetaiotaomicron VPI-5482
Annotation: putative nucleotide-sugar dehydratase (NCBI ptt file)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to bth:BT_2880)Predicted SEED Role
"dTDP-glucose 4,6-dehydratase (EC 4.2.1.46)" in subsystem Rhamnose containing glycans or dTDP-rhamnose synthesis or linker unit-arabinogalactan synthesis (EC 4.2.1.46)
MetaCyc Pathways
- dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
- dTDP-N-acetylviosamine biosynthesis (3/4 steps found)
- O-antigen building blocks biosynthesis (E. coli) (8/11 steps found)
- dTDP-4-O-demethyl-β-L-noviose biosynthesis (3/5 steps found)
- dTDP-β-D-fucofuranose biosynthesis (2/4 steps found)
- dTDP-6-deoxy-α-D-allose biosynthesis (2/4 steps found)
- dTDP-N-acetylthomosamine biosynthesis (2/4 steps found)
- dTDP-D-desosamine biosynthesis (3/6 steps found)
- dTDP-L-daunosamine biosynthesis (3/6 steps found)
- dTDP-sibirosamine biosynthesis (3/6 steps found)
- dTDP-α-D-mycaminose biosynthesis (2/5 steps found)
- dTDP-3-acetamido-α-D-fucose biosynthesis (2/5 steps found)
- dTDP-3-acetamido-3,6-dideoxy-α-D-glucose biosynthesis (2/5 steps found)
- dTDP-β-L-digitoxose biosynthesis (3/7 steps found)
- dTDP-β-L-olivose biosynthesis (3/7 steps found)
- dTDP-α-D-ravidosamine and dTDP-4-acetyl-α-D-ravidosamine biosynthesis (2/6 steps found)
- dTDP-β-L-4-epi-vancosamine biosynthesis (3/8 steps found)
- dTDP-β-L-megosamine biosynthesis (3/8 steps found)
- dTDP-β-L-mycarose biosynthesis (2/7 steps found)
- superpathway of enterobacterial common antigen biosynthesis (4/10 steps found)
- dTDP-α-D-forosamine biosynthesis (3/9 steps found)
- dTDP-α-D-olivose, dTDP-α-D-oliose and dTDP-α-D-mycarose biosynthesis (3/9 steps found)
- superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (6/19 steps found)
- superpathway of novobiocin biosynthesis (4/19 steps found)
- superpathway of erythromycin biosynthesis (3/19 steps found)
- superpathway of megalomicin A biosynthesis (4/22 steps found)
- superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (11/33 steps found)
- superpathway of dTDP-glucose-derived antibiotic building blocks biosynthesis (3/23 steps found)
KEGG Metabolic Maps
- Biosynthesis of vancomycin group antibiotics
- Polyketide sugar unit biosynthesis
- Streptomycin biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.46
Use Curated BLAST to search for 4.2.1.46
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q8A3S4 at UniProt or InterPro
Protein Sequence (344 amino acids)
>BT2880 putative nucleotide-sugar dehydratase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482) MMTYYDDIRKVQDLHLPWEILTDINILIVGASGLIGRALVDTLMQLPDKTFHLYAGVRDL VYAQSCFMRYKDDESFTLIQCDVTALIPFDIDFHYIIHAASYAGPAAFHNDPVGVMKANI LGVDNLFSYGEQHNLRRLLYVSSGEVYGEGNGIPFREEDSGSLDWASLRACYPAAKRTAE TLCIAYAAQFQIETVIARPCHIYGPFYTSKDDRAYAQFIRNVLAGENIILRSSGLQQRSW CYVVDCVFALLYVLLKGKTKNAYNIADVRSNVSIREFAEMIALKSEREVIFDLPDNTGKN KPIISQAIFNTEKINKIGWFPQWKLEEGVSHTLNTLISVDGTYI