Protein Info for BT2694 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative urocanate hydratase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 663 PF17391: Urocanase_N" amino acids 79 to 204 (126 residues), 170.4 bits, see alignment E=2.1e-54 TIGR01228: urocanate hydratase" amino acids 88 to 632 (545 residues), 425.7 bits, see alignment E=1.4e-131 PF01175: Urocanase" amino acids 207 to 430 (224 residues), 265.1 bits, see alignment E=6.8e-83 PF17392: Urocanase_C" amino acids 435 to 630 (196 residues), 271.6 bits, see alignment E=5.1e-85

Best Hits

Swiss-Prot: 50% identical to HUTU_DICDI: Probable urocanate hydratase (uroc1) from Dictyostelium discoideum

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 100% identity to bth:BT_2694)

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A4A9 at UniProt or InterPro

Protein Sequence (663 amino acids)

>BT2694 putative urocanate hydratase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKITLGNTLPPYPAFIEGIRRAPDRSYMLTPAQTATALKNALRYIPLELHEQLAPEFMEE
LRTRGRIYGYRFRPAGDLKARPIDEYRGKCVEGKAFQVMIDNNLCFDIALYPYELVTYGE
TGQVCQNWMQYLLIKQYLEELTPEQTLVIESGHPLGLFRSRPDAPRVIITNSMMIGQFDN
QHDWHIAAQMGVANYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLGIPQDKDLRGHLF
VSSGLGGMSGAQPKAAEIAGAASIIAEVDSSRIETRYRQGWVGHVTQDLSEAFRLAKEAM
ERREPCSIAYHGNVVDLLEYAEREQIHIELLSDQTSCHAVYEGGYCPVGLTFEERTRLLH
ESPDQFRRLADASLRRHFEVIRKLVACGTYFFDYGNSFMKAIYDAGVKEISRNGVDEKDG
FIWPSYVEDIMGPQLFDYGYGPFRWVCLSGRHEDLIKTDRAAMECIDVNRRGQDLDNYNW
IRDAEKNRLVVGTQARILYQDAVGRMNIALRFNEMVRRGEVGPIMLGRDHHDVSGTDSPF
RETSNIKDGSNVMADMAVQCFAGNCARGMSLVALHNGGGVGIGKAINGGFGMVCDGSERV
DEILRSAMLWDVMGGVARRSWARNPHAMETSDAFNESHSEGYHITMPYLADDELIKKTIK
EAL