Protein Info for BT2686 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative cation efflux transporter (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1052 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 332 to 351 (20 residues), see Phobius details amino acids 358 to 377 (20 residues), see Phobius details amino acids 383 to 408 (26 residues), see Phobius details amino acids 429 to 449 (21 residues), see Phobius details amino acids 461 to 488 (28 residues), see Phobius details amino acids 528 to 549 (22 residues), see Phobius details amino acids 865 to 883 (19 residues), see Phobius details amino acids 891 to 911 (21 residues), see Phobius details amino acids 917 to 942 (26 residues), see Phobius details amino acids 963 to 982 (20 residues), see Phobius details amino acids 994 to 1024 (31 residues), see Phobius details PF00873: ACR_tran" amino acids 6 to 1020 (1015 residues), 859.7 bits, see alignment E=2.8e-262 PF03176: MMPL" amino acids 299 to 490 (192 residues), 29.6 bits, see alignment E=3.6e-11 amino acids 831 to 1034 (204 residues), 21.9 bits, see alignment E=7.6e-09

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 100% identity to bth:BT_2686)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A4B7 at UniProt or InterPro

Protein Sequence (1052 amino acids)

>BT2686 putative cation efflux transporter (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MSLYEGAVKKPIMTSLCFLAVVIFGLFSLSKLPIDLYPDIDTNTIMVMTAYPGASASDIE
NNVTRPLENTLNAVSNLKHITSRSSENMSLITLEFEFGNDIDVLTNDVRDKLDMVSSQLP
DDVENPIIFKFSTDMIPIVLLSVQANESQAALYKILDDRVVNPLARIPGVGTVSISGAPQ
REIQVYCDPNKLEAYNLSIETISSIIGAENKNIPGGNFDIGSETYALRVEGEFDDSRQLA
DIVVGTHNGANVFLRDVARIVDTVEERAQETYNNGVQGAMIVVQKQSGANSVEISRKVEE
ALPRLQKNLPSDVKLGVIVDTSDNILNTIDSLAETVMYALLFVVIVVFLFLGRWRATLII
CITIPLSLIASFIYLAITGNTINIISLSSLSIAIGMVVDDAIVVLENVTTHIERGSDPKQ
AAVHGTNEVAISVIASTLTMIAVFFPLTMVSGMSGVLFKQLGWMMCAIMFVSTVAALSLT
PMLCSQLLRLQKRPSKMFKLFFTPIEKALDALDTGYAKMLNWAVRHRPVVIVGCIAFFVV
SLLCAKGIGTEFFPAQDNARIAVQLELPIGTRKEIAQELSEKLTNQWLTKYKDIMKVCNY
TVGQADSDNTWASMQDNGSHIISFNISLVDPGDRDISLEAVCDEMRQDLKGYPEFSKAQV
ILGGSNTGMSAQASADFEIYGYDMTMTDSVAARLKRELLTVKGVTEVNISRSDYQPEYQV
DFDREKLAMHGLNLATAGNYLRNRINGAVASKYREDGDEYDIKVRYAPEYRTSLESIENI
LIYNAKGESVRVKDVGKVVERFAPPTIERKDRERIVTVSAVISGAPLGDVVAAGNKLIDK
MDIPGEITIQISGSYEDQQDSFRDLGTLGILIVILVFIVMAAQFESLTYPFIIMFSLPFA
FSGVLMALFFTGSTLSVMSLLGGIMLIGIVVKNGIVLIDYITLCRERGMAVINSVVTSGK
SRLRPVLMTTATTVLGMIPMAIGGGQGSEMWSPMAIAVIGGLTVSTVLTLVLIPTLYCVF
AGTGIKNRRRKLHRKRELDVYFQEHKDEIIKK