Protein Info for BT2617 in Bacteroides thetaiotaomicron VPI-5482

Annotation: reverse transcriptase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 TIGR04416: group II intron reverse transcriptase/maturase" amino acids 58 to 402 (345 residues), 419.2 bits, see alignment E=7.1e-130 PF00078: RVT_1" amino acids 114 to 320 (207 residues), 135.4 bits, see alignment E=2.4e-43 PF08388: GIIM" amino acids 338 to 416 (79 residues), 72.8 bits, see alignment E=1.9e-24

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_2617)

Predicted SEED Role

"Retron-type RNA-directed DNA polymerase (EC 2.7.7.49)" (EC 2.7.7.49)

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.49

Use Curated BLAST to search for 2.7.7.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A4I2 at UniProt or InterPro

Protein Sequence (468 amino acids)

>BT2617 reverse transcriptase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKERMQKTSAQAHDFPQRARTESEWYEGVQTFMWMTEDNIVEVPFDKEHLLEIILSPSNL
NKAYKAVVRNNGSGGIDKMSCEQLLSWLKANKDELIISLQSGTYRPNPVRRVEIPKDNGK
KRLLGIPTVVDRLVQQAINQVLTLIYERQFSKTSYGFRPQRGCHDALRKAQKIVSEGYIY
VVDLDLERFFDTVSHSKLIEILSRTIKDGRVISLIHKYLRSGVINRGMFEMSTEGTPQGG
PLSPLLSNIMLNELDKELERRGHPFVRYADDAMIFCKSKRAAKRVRESITLFIEGKLFLK
VNHEKTVVSYVKGVKFLGYSFYVKKGDCILLVHSKSKNKMKSKLKELTSRSNGWGYEKRK
QKLKDYIRGWIAYFCLAQMKRLCIETDEWLRRRIRMCIWKSWKNAKTRVANLKKCGVSEW
QAYQWGNTRLGYWRVSNSPIVTFVMSNDKLRKAGYMEFMDCYLKWCPK