Protein Info for BT2527 in Bacteroides thetaiotaomicron VPI-5482

Annotation: uridine kinase (uridine monophosphokinase) (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: K00876, uridine kinase [EC: 2.7.1.48] (inferred from 100% identity to bth:BT_2527)

Predicted SEED Role

"Uridine kinase (EC 2.7.1.48)" (EC 2.7.1.48)

MetaCyc Pathways

superpathway of pyrimidine ribonucleosides salvage (9/10 steps found)
pyrimidine ribonucleosides salvage I (3/3 steps found)
nucleoside and nucleotide degradation (archaea) (4/10 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.48

Use Curated BLAST to search for 2.7.1.48

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A4S0 at UniProt or InterPro

Protein Sequence (557 amino acids)

>BT2527 uridine kinase (uridine monophosphokinase) (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKQMLQICCKNNNIYKEFPIGSSLLDIYYGFNLNFPYQVVSAKVNNRSEGLNFKVYNNKD
IEFLDVRDSSGMRTYVRSLCFVLFKAVSELFPEGKLFVEHPVSKGYFCNLRIGRPITLED
VTRIKQRMQEIIAENISYHRIECHTAEAVRVFSERGMNDKVRLLETSGSLYTYYYTLGDT
VDYYYGNLLPSTGYIKLFDIVKYYDGLLLRIPNKENPDVLEEVVKQEKMLDVFKEYLNWS
YIMGLNNAGDFNLACEEGHATDLINVAEALQEKKIAQIADTIFHRGENGDRVKLILISGP
SSSGKTTFSKRLSIQLMTNGLKPFPISLDNYFVDREETPLDENGNYDYESLYALDLELFN
QQLQALLRGEEVELPRFNFSLGKKEYKGDKLKIEDNTILILEGIHALNPELTPHIPDEKK
FKIYVSALTTISLDDHNWIPTTDNRLLRRIIRDFNYRGYSARETISRWPSVRAGEDKWIF
PYQENADVMFNSALLFEFAVLRLHAEPILMGVPRNCPEYCEAYRLLKFIKYFVPVQDKEI
PPTSLLREFLGGSSFKY