Protein Info for BT2512 in Bacteroides thetaiotaomicron VPI-5482

Annotation: cation-transporting ATPase, P-type, putative zinc-transporting ATPase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 652 transmembrane" amino acids 31 to 51 (21 residues), see Phobius details amino acids 59 to 77 (19 residues), see Phobius details amino acids 89 to 107 (19 residues), see Phobius details amino acids 113 to 119 (7 residues), see Phobius details amino acids 262 to 284 (23 residues), see Phobius details amino acids 296 to 320 (25 residues), see Phobius details amino acids 601 to 621 (21 residues), see Phobius details amino acids 627 to 646 (20 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 94 to 646 (553 residues), 519 bits, see alignment E=2.8e-159 TIGR01512: cadmium-translocating P-type ATPase" amino acids 94 to 648 (555 residues), 454.5 bits, see alignment E=6.8e-140 TIGR01494: HAD ATPase, P-type, family IC" amino acids 116 to 624 (509 residues), 209.5 bits, see alignment E=1e-65 PF00122: E1-E2_ATPase" amino acids 144 to 328 (185 residues), 137.8 bits, see alignment E=4.6e-44 PF00702: Hydrolase" amino acids 345 to 555 (211 residues), 93.4 bits, see alignment E=3.6e-30 PF08282: Hydrolase_3" amino acids 527 to 591 (65 residues), 26.1 bits, see alignment E=1e-09

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 100% identity to bth:BT_2512)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A4T5 at UniProt or InterPro

Protein Sequence (652 amino acids)

>BT2512 cation-transporting ATPase, P-type, putative zinc-transporting ATPase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MIMGHCSCCAHTHECAPEKHIEKKESIFAEYWKVGLSFILLISGIIMNALELPFFREGYF
SLIWYVVAYLPVGLPVMKEAWESMKDKDYFSEFTLMFVATLGAFYIGEYPEGVAVMLFYS
VGELFQEKAVDKAKRNIGALLDVRPEEAAVVRDERVVIENPQSVKVGETIEIKTGGRVPL
DGMMLNEVAAFNTAALTGESVPRSIRMGEEVLAGMIVTDKVIRIKVIRPFDKSALARILE
LVQNASERKAPAELFIRKFARVYTPIVIGLAVLIVLLPFIYSLITPQFLFTFNDWLYRAL
VFLVISCPCALVVSIPLGYFGGIGAASRLGILFKGGNYLDAVTKINTVVFDKTGTLTKGT
FEVQFCNCESGVSEEELIRMIASVESSSTHPIAKAVVNYAGQRDIELSSVTDSKEYAGLG
LEAAVNGIQVLAGNGRLLSKFQIEYPPELLSITDTIVVCAIGNKYAGYLLLSDSLKEDAK
IAIQNLKALGIQNIQILSGDKQSIVSNFAEKLGISEAYGDLLPDGKVKHLEELRQHTENQ
VAFVGDGMNDAPVLALSNVGIAMGGLGSDAAIETADVVIQTDQPSKVAEAIKVGKLTRRI
VWQNISLAFGVKLLVLILGAGGLATLWEAVFADVGVALIAIMNAVRIQKMIK