Protein Info for BT2423 in Bacteroides thetaiotaomicron VPI-5482

Annotation: K+-transporting ATPase C chain (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 189 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details TIGR00681: K+-transporting ATPase, C subunit" amino acids 3 to 186 (184 residues), 169.7 bits, see alignment E=3.5e-54 PF02669: KdpC" amino acids 5 to 186 (182 residues), 231.7 bits, see alignment E=2.8e-73

Best Hits

Swiss-Prot: 100% identical to KDPC_BACTN: Potassium-transporting ATPase KdpC subunit (kdpC) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K01548, K+-transporting ATPase ATPase C chain [EC: 3.6.3.12] (inferred from 100% identity to bth:BT_2423)

MetaCyc: 38% identical to K+ transporting P-type ATPase subunit KdpC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-2 [EC: 7.2.2.6]

Predicted SEED Role

"Potassium-transporting ATPase C chain (EC 3.6.3.12) (TC 3.A.3.7.1)" in subsystem Potassium homeostasis (EC 3.6.3.12, TC 3.A.3.7.1)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.12

Use Curated BLAST to search for 3.6.3.12 or 7.2.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A521 at UniProt or InterPro

Protein Sequence (189 amino acids)

>BT2423 K+-transporting ATPase C chain (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKTLFKSLKITLVFCVFFSVFYILILWLFAQVAGPNKGNAEVATLDGKVVGAANVGQMFT
KDIYFWGRPSCAGDGYDASSSSGSNKGPTNPEYLAEVEARIDTFLVHHPYLSRKDVPAEM
VTASASGLDPNITPQCAYVQVKRVAQARGLTENQVKEIVDQSVEKPLLGIFGTEKINVLK
LNIALEENK